The etiology of idiopathic Parkinson's disease (iPD) is multifactorial, and both genetics and
environmental exposures are risk factors. While mutations in leucine-rich repeat kinase-2 …

Recent technological advances in the field of genomics offer conservation managers and
practitioners new tools to explore for conservation applications. Many of these tools are well …

Mutations enhancing the kinase activity of leucine-rich repeat kinase-2 (LRRK2) cause
Parkinson's disease (PD) and therapies that reduce LRRK2 kinase activity are being tested …

Gain-of-function mutations in LRRK2, which encodes the leucine-rich repeat kinase 2
(LRRK2), are the most common genetic cause of late-onset Parkinson's disease. LRRK2 is …

Mutations in the human leucine rich repeat protein kinase-2 (LRRK2) create risk factors for
Parkinson's disease, and pathological functions of LRRK2 are often correlated with aberrant …

Leucine-Rich Repeat Kinase 2 (LRRK2) is a large, multidomain protein with dual kinase and
GTPase function that is commonly mutated in both familial and idiopathic Parkinson's …

The 2 major molecular switches in biology, kinases and GTPases, are both contained in the
Parkinson disease–related leucine-rich repeat kinase 2 (LRRK2). Using hydrogen …

Parkinson's disease (PD) is the second most prevalent neurodegenerative disease,
characterized by the specific loss of dopaminergic neurons in the midbrain. The …

Mutations in the multidomain protein Leucine-rich-repeat kinase 2 (LRRK2) have been
identified as a genetic risk factor for both sporadic and familial Parkinson's disease (PD) …

Drug research and development is a multidisciplinary field with its own successes. Yet,
given the complexity of the process, it also faces challenges over the long development …