Metabolomics in cancer research and emerging applications in clinical oncology

DR Schmidt, R Patel, DG Kirsch… - CA: a cancer journal …, 2021 - Wiley Online Library
Cancer has myriad effects on metabolism that include both rewiring of intracellular
metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor …

Guide to metabolomics analysis: a bioinformatics workflow

Y Chen, EM Li, LY Xu - Metabolites, 2022 - mdpi.com
Metabolomics is an emerging field that quantifies numerous metabolites systematically. The
key purpose of metabolomics is to identify the metabolites corresponding to each biological …

[HTML][HTML] The human urine metabolome

S Bouatra, F Aziat, R Mandal, AC Guo, MR Wilson… - PloS one, 2013 - journals.plos.org
Urine has long been a “favored” biofluid among metabolomics researchers. It is sterile, easy-
to-obtain in large volumes, largely free from interfering proteins or lipids and chemically …

Mass spectrometric based approaches in urine metabolomics and biomarker discovery

MM Khamis, DJ Adamko… - Mass spectrometry …, 2017 - Wiley Online Library
Urine metabolomics has recently emerged as a prominent field for the discovery of non‐
invasive biomarkers that can detect subtle metabolic discrepancies in response to a specific …

Plasma free amino acid profiling of five types of cancer patients and its application for early detection

Y Miyagi, M Higashiyama, A Gochi, M Akaike… - PloS one, 2011 - journals.plos.org
Background Recently, rapid advances have been made in metabolomics-based, easy-to-
use early cancer detection methods using blood samples. Among metabolites, profiling of …

Metabolomic approaches for detection and identification of biomarkers and altered pathways in bladder cancer

NA di Meo, D Loizzo, SD Pandolfo, R Autorino… - International Journal of …, 2022 - mdpi.com
Metabolomic analysis has proven to be a useful tool in biomarker discovery and the
molecular classification of cancers. In order to find new biomarkers, and to better understand …

Cancer metabolomic markers in urine: evidence, techniques and recommendations

SS Dinges, A Hohm, LA Vandergrift, J Nowak… - Nature reviews …, 2019 - nature.com
Urinary tests have been used as noninvasive, cost-effective tools for screening, diagnosis
and monitoring of diseases since ancient times. As we progress through the 21st century …

Global urinary metabolic profiling procedures using gas chromatography–mass spectrometry

ECY Chan, KK Pasikanti, JK Nicholson - Nature protocols, 2011 - nature.com
The role of urinary metabolic profiling in systems biology research is expanding. This is
because of the use of this technology for clinical diagnostic and mechanistic studies and for …

A support vector machine-recursive feature elimination feature selection method based on artificial contrast variables and mutual information

X Lin, F Yang, L Zhou, P Yin, H Kong, W Xing… - … of chromatography B, 2012 - Elsevier
Filtering the discriminative metabolites from high dimension metabolome data is very
important in metabolomics study. Support vector machine-recursive feature elimination …

Metabolic profiling regarding pathogenesis of idiopathic pulmonary fibrosis

YP Kang, SB Lee, J Lee, HM Kim… - Journal of proteome …, 2016 - ACS Publications
Idiopathic pulmonary fibrosis (IPF) is a progressive, eventually fatal disease characterized
by fibrosis of the lung parenchyma and loss of lung function. IPF is believed to be caused by …