Whole-heart ventricular arrhythmia modeling moving forward: Mechanistic insights and translational applications
Ventricular arrhythmias are the primary cause of sudden cardiac death and one of the
leading causes of mortality worldwide. Whole-heart computational modeling offers a unique …
leading causes of mortality worldwide. Whole-heart computational modeling offers a unique …
Translational applications of computational modelling for patients with cardiac arrhythmias
Cardiac arrhythmia is associated with high morbidity, and its underlying mechanisms are
poorly understood. Computational modelling and simulation approaches have the potential …
poorly understood. Computational modelling and simulation approaches have the potential …
MaskFusionNet: A dual-stream fusion model with masked pre-training mechanism for rPPG measurement
Remote photoplethysmography (rPPG) has considerable significance in areas such as
disease diagnosis and emotion analysis. Recent rPPG models have demonstrated excellent …
disease diagnosis and emotion analysis. Recent rPPG models have demonstrated excellent …
Graft–host coupling changes can lead to engraftment arrhythmia: a computational study
After myocardial infarction (MI), a significant portion of heart muscle is replaced with scar
tissue, progressively leading to heart failure. Human pluripotent stem cell‐derived …
tissue, progressively leading to heart failure. Human pluripotent stem cell‐derived …
The role of the Cx43/Cx45 gap junction voltage gating on wave propagation and arrhythmogenic activity in cardiac tissue
Gap junctions (GJs) formed of connexin (Cx) protein are the main conduits of electrical
signals in the heart. Studies indicate that the transitional zone of the atrioventricular (AV) …
signals in the heart. Studies indicate that the transitional zone of the atrioventricular (AV) …
Late-gadolinium enhancement interface area and electrophysiological simulations predict arrhythmic events in patients with nonischemic dilated cardiomyopathy
Objectives This study sought to investigate whether shape-based late gadolinium
enhancement (LGE) metrics and simulations of re-entrant electrical activity are associated …
enhancement (LGE) metrics and simulations of re-entrant electrical activity are associated …
[HTML][HTML] Ventricular tachycardia
C Foth, MK Gangwani, H Alvey - 2018 - europepmc.org
Objectives: Explain the pathophysiologic basis of ventricular tachycardia. Summarize the
differential diagnoses of ventricular tachycardia. Describe the evaluation and management …
differential diagnoses of ventricular tachycardia. Describe the evaluation and management …
Fibroblast mediated dynamics in diffusively uncoupled myocytes: a simulation study using 2-cell motifs
S Sridhar, RH Clayton - Scientific Reports, 2024 - nature.com
In healthy hearts myocytes are typically coupled to nearest neighbours through gap
junctions. Under pathological conditions such as fibrosis, or in scar tissue, or across ablation …
junctions. Under pathological conditions such as fibrosis, or in scar tissue, or across ablation …
Fibrosis modeling choice affects morphology of ventricular arrhythmia in non-ischemic cardiomyopathy
Introduction: Patients with non-ischemic cardiomyopathy (NICM) are at risk for ventricular
arrhythmias, but diagnosis and treatment planning remain a serious clinical challenge …
arrhythmias, but diagnosis and treatment planning remain a serious clinical challenge …
[HTML][HTML] Re-entry in models of cardiac ventricular tissue with scar represented as a Gaussian random field
RH Clayton, S Sridhar - Frontiers in Physiology, 2024 - frontiersin.org
Introduction: Fibrotic scar in the heart is known to act as a substrate for arrhythmias. Regions
of fibrotic scar are associated with slowed or blocked conduction of the action potential, but …
of fibrotic scar are associated with slowed or blocked conduction of the action potential, but …