Whole-heart ventricular arrhythmia modeling moving forward: Mechanistic insights and translational applications

E Sung, S Etoz, Y Zhang, NA Trayanova - Biophysics reviews, 2021 - pubs.aip.org
Ventricular arrhythmias are the primary cause of sudden cardiac death and one of the
leading causes of mortality worldwide. Whole-heart computational modeling offers a unique …

Translational applications of computational modelling for patients with cardiac arrhythmias

SF Bifulco, N Akoum, PM Boyle - Heart, 2021 - heart.bmj.com
Cardiac arrhythmia is associated with high morbidity, and its underlying mechanisms are
poorly understood. Computational modelling and simulation approaches have the potential …

MaskFusionNet: A dual-stream fusion model with masked pre-training mechanism for rPPG measurement

Y Zhang, J Shi, J Wang, Y Zong… - IEEE Transactions on …, 2024 - ieeexplore.ieee.org
Remote photoplethysmography (rPPG) has considerable significance in areas such as
disease diagnosis and emotion analysis. Recent rPPG models have demonstrated excellent …

Graft–host coupling changes can lead to engraftment arrhythmia: a computational study

CE Gibbs, S Marchianó, K Zhang, X Yang… - The Journal of …, 2023 - Wiley Online Library
After myocardial infarction (MI), a significant portion of heart muscle is replaced with scar
tissue, progressively leading to heart failure. Human pluripotent stem cell‐derived …

The role of the Cx43/Cx45 gap junction voltage gating on wave propagation and arrhythmogenic activity in cardiac tissue

K Maciunas, M Snipas, T Kraujalis, L Kraujalienė… - Scientific reports, 2023 - nature.com
Gap junctions (GJs) formed of connexin (Cx) protein are the main conduits of electrical
signals in the heart. Studies indicate that the transitional zone of the atrioventricular (AV) …

Late-gadolinium enhancement interface area and electrophysiological simulations predict arrhythmic events in patients with nonischemic dilated cardiomyopathy

G Balaban, BP Halliday, B Porter, W Bai… - Clinical …, 2021 - jacc.org
Objectives This study sought to investigate whether shape-based late gadolinium
enhancement (LGE) metrics and simulations of re-entrant electrical activity are associated …

[HTML][HTML] Ventricular tachycardia

C Foth, MK Gangwani, H Alvey - 2018 - europepmc.org
Objectives: Explain the pathophysiologic basis of ventricular tachycardia. Summarize the
differential diagnoses of ventricular tachycardia. Describe the evaluation and management …

Fibroblast mediated dynamics in diffusively uncoupled myocytes: a simulation study using 2-cell motifs

S Sridhar, RH Clayton - Scientific Reports, 2024 - nature.com
In healthy hearts myocytes are typically coupled to nearest neighbours through gap
junctions. Under pathological conditions such as fibrosis, or in scar tissue, or across ablation …

Fibrosis modeling choice affects morphology of ventricular arrhythmia in non-ischemic cardiomyopathy

L Myklebust, MM Maleckar, H Arevalo - Frontiers in Physiology, 2024 - frontiersin.org
Introduction: Patients with non-ischemic cardiomyopathy (NICM) are at risk for ventricular
arrhythmias, but diagnosis and treatment planning remain a serious clinical challenge …

[HTML][HTML] Re-entry in models of cardiac ventricular tissue with scar represented as a Gaussian random field

RH Clayton, S Sridhar - Frontiers in Physiology, 2024 - frontiersin.org
Introduction: Fibrotic scar in the heart is known to act as a substrate for arrhythmias. Regions
of fibrotic scar are associated with slowed or blocked conduction of the action potential, but …