The CXC chemokine receptor 4 (CXCR4) in endothelial cells (ECs) and vascular smooth
muscle cells (VSMCs) is crucial for vascular integrity. The atheroprotective functions of …

The long-term survival rate of cancer patients has been increasing as a result of advances in
treatments and precise medical management. The evidence has accumulated that the …

A new perspective on the complex cellular landscape of the aorta, specifically the
atherosclerosis-prone regions, confirm that intimal accumulation of lipid, monocyte …

Histopathological studies have revealed key processes of atherosclerotic plaque
thrombosis. However, the diversity and complexity of lesion types highlight the need for …

Lipid accumulation in macrophages (Mφs) is a hallmark of atherosclerosis, yet how lipid
accumulation affects inflammatory responses through rewiring of Mφ metabolism is poorly …

BACKGROUND: Atherosclerosis preferentially occurs in arterial regions of disturbed blood
flow, and stable flow (s-flow) protects against atherosclerosis by incompletely understood …

One of the hallmarks of atherosclerosis is ongoing accumulation of macrophages in the
artery intima beginning at disease onset. Monocyte recruitment contributes to increasing …

Objective The gut hormone glucose-dependent insulinotropic polypeptide (GIP) stimulates
beta cell function and improves glycemia through its incretin actions. GIP also regulates …

Endothelial cells line every blood vessel and thereby serve as an interface between the
blood and the vessel wall. They have critical functions for maintaining homeostasis and …

Background The deSUMOylase sentrin-specific isopeptidase 2 (SENP2) plays a crucial role
in atheroprotection. However, the phosphorylation of SENP2 at T368 under disturbed flow …