This paper reviews studies examining the pharmacological interactions and epidemiology of
the combined use of opioids and benzodiazepines (BZDs). A search of English language …

When opiates are administered by the epidural and spinal routes, itching occurs as a side
effect. We reviewed 52 reports in the literature of the use of epidural and spinal opiates to …

A review of pharmacological, neuroanatomical, electrophysiological, and behavioral data
indicates that systems controlling cardiovascular function are closely coupled to systems …

γ-Hydroxybutyrate is a metabolite of GABA which is synthesized and accumulated by
neurons in brain. This substance is present in micromolar quantities in all brain regions …

There has been increasing attention in the United States to problems of abuse of gamma-
hydroxybutyrate (GHB), with some evidence for problems in other parts of the world as well …

The discovery of an endogenous opioid-mediated analgesic system1, 2 has led to the
search for its physiological roles and how it might be activated in natural conditions …

IF endorphins modulate pain, then naloxone should affect pain behaviour even in subjects
who have not received exogenous opiates. However, some naloxone studies claim a lack of …

Since the discovery of endogenous opioid peptides in brain (68, 69, 97,113, 128) and the
pituitary gland (26, 81,105,125) there has been considerable interest in their possible roles …

This review summarizes recent developments on the effects of opiate drugs and the various
endogenous opioid peptides on breathing. These developments include demonstration of …

Naloxone hydrochloride, a synthetic N-allyl derivative of oxymorphone, is an effective agent
for the reversal of the cardiovascular and respiratory depression associated with narcotic …