In general perturbation methods starts with a known exact solution of a problem and add
“small” variation terms in order to approach to a solution for a related problem without known …

In silico discovery of interactions between drug compounds and target proteins is of core
importance for improving the efficiency of the laborious and costly experimental …

Complex phenotypes emerge from the interactions of thousands of macromolecules that are
organized in multimolecular complexes and interacting functional modules. In turn, modules …

The disappointing results obtained in recent clinical trials renew the interest in experimental/
computational techniques for the discovery of neuroprotective drugs. In this context …

Multiplexed biological assays provide multiple measurements of cellular parameters in the
same test. In this work, we have trained and tested an Artificial Neural Network (ANN) model …

Aging and life quality is an important research topic nowadays in areas such as life
sciences, chemistry, pharmacology, etc. People live longer, and, thus, they want to spend …

Background Antimicrobial peptides attract considerable interest as novel agents to combat
infections. Their long-time potency across bacteria, viruses and fungi as part of diverse …

A high level of chromosomal aberrations in peripheral blood lymphocytes may be an early
marker of cancer risk, but data on risk of specific cancers and types of chromosomal …

Mycobacteria represent a group of pathogens which cause serious diseases in mammals,
including the lethal tuberculosis (Mycobacterium tuberculosis). Despite the mortality of this …

Abstract Quantitative Structure–Activity (mt-QSAR) techniques may become an important
tool for prediction of cytotoxicity and High-throughput Screening (HTS) of drugs to rationalize …