Anabolic–androgenic steroids: How do they work and what are the risks?

P Bond, DL Smit, W de Ronde - Frontiers in Endocrinology, 2022 - frontiersin.org
Anabolic–androgenic steroids (AAS) are a class of hormones that are widely abused for
their muscle-building and strength-increasing properties in high, nontherapeutic, dosages …

Novel and future lipid-modulating therapies for the prevention of cardiovascular disease

J Brandts, KK Ray - Nature Reviews Cardiology, 2023 - nature.com
Lowering the levels of LDL cholesterol in the plasma has been shown to reduce the risk of
atherosclerotic cardiovascular disease (ASCVD). Several other lipoproteins, such as …

[HTML][HTML] Bempedoic acid and cardiovascular outcomes in statin-intolerant patients

SE Nissen, AM Lincoff, D Brennan… - … England Journal of …, 2023 - Mass Medical Soc
Background Bempedoic acid, an ATP citrate lyase inhibitor, reduces low-density lipoprotein
(LDL) cholesterol levels and is associated with a low incidence of muscle-related adverse …

[HTML][HTML] Editor's choice--European Society for Vascular Surgery (ESVS) 2024 clinical practice guidelines on the management of asymptomatic lower limb peripheral …

J Nordanstig, CA Behrendt, I Baumgartner… - European Journal of …, 2024 - Elsevier
BIOTRONIK's First in Man study of the Passeo-18 LUX drug releasing PTA Balloon Catheter
vs. the uncoated Passeo-18 PTA balloon catheter in subjects requiring revascularisation of …

KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease

PE Stevens, SB Ahmed, JJ Carrero… - Kidney …, 2024 - kidney-international.org
This article is published as part of a supplement sponsored by Kidney Disease: Improving
Global Outcomes (KDIGO). The opinions or views expressed in this supplement are those of …

Epidemiology of the idiopathic inflammatory myopathies

T Khoo, JB Lilleker, BYH Thong, V Leclair… - Nature Reviews …, 2023 - nature.com
The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of systemic
autoimmune diseases that affect the skeletal muscles and can also involve the skin, joints …

Pragmatic evaluation of events and benefits of lipid lowering in older adults (PREVENTABLE): Trial design and rationale

J Joseph, NM Pajewski, RJ Dolor… - Journal of the …, 2023 - Wiley Online Library
Whether initiation of statins could increase survival free of dementia and disability in adults
aged≥ 75 years is unknown. PREVENTABLE, a double‐blind, placebo‐controlled …

[HTML][HTML] Cholesterol lowering drugs

KR Feingold - 2016 - europepmc.org
There are currently eight different classes of drugs available for lowering cholesterol levels.
There are currently seven HMG-CoA reductase inhibitors (statins) approved for lowering …

Clinical potential of inclisiran for patients with a high risk of atherosclerotic cardiovascular disease

T Nishikido - Cardiovascular Diabetology, 2023 - Springer
Elevated low-density lipoprotein cholesterol (LDL-C) level is associated with an increased
risk of atherosclerotic cardiovascular disease. Although high-intensity lipid-lowering …

[HTML][HTML] Statins and diabetes: what are the connections?

N Sattar - Best practice & research Clinical endocrinology & …, 2023 - Elsevier
Randomized trials suggest moderate-intensity statins increase type 2 diabetes risk by
around 11% with a potential further 12% moving to high-intensity statins, such that high …