Estrogens have been implicated in the pathogenesis of various cancers, with increasing
concern regarding the overall rising incidence of disease and exposure to environmental …

G protein-coupled receptors (GPCRs) are the largest class of transmembrane receptors
encoded in the human genome, and they initiate cellular responses triggered by a plethora …

Cellular signaling involves a large repertoire of membrane receptors operating in
overlapping spatiotemporal regimes and targeting many common intracellular effectors …

Noncanonical G protein activation and inactivation, particularly for the Gαi/s protein
subfamilies, have long been a focus of chemical research. Combinatorial libraries were …

Many cancer-driving protein targets remain undruggable due to a lack of binding molecular
scaffolds. In this regard, octahedral metal complexes with unique and versatile three …

Heterotrimeric G proteins (Gαβγ) are molecular switches that relay signals from 7-
transmembrane receptors located at the cell surface to the cytoplasm. The function of these …

The small molecule IGGi-11 targets Gαi subunits of heterotrimeric guanine nucleotide-
binding proteins. Gα subunits are activated by G-protein-coupled receptors in response to …

Regulator of G protein signaling 12 (RGS12) belongs to the superfamily of RGS proteins
defined by a conserved RGS domain that canonically binds and deactivates heterotrimeric G …

Lung cancer is the leading cause of cancer-related deaths in Japan, with high morbidity
rates among younger individuals and women. Treatment options primarily include surgical …