Antibody modulation of B cell responses—Incorporating positive and negative feedback

JG Cyster, PC Wilson - Immunity, 2024 - cell.com
Antibodies are powerful modulators of ongoing and future B cell responses. While the
concept of antibody feedback has been appreciated for over a century, the topic has seen a …

Borrelia burgdorferi Manipulates Innate and Adaptive Immunity to Establish Persistence in Rodent Reservoir Hosts

KE Tracy, N Baumgarth - Frontiers in immunology, 2017 - frontiersin.org
Borrelia burgdorferi sensu lato species complex is capable of establishing persistent
infections in a wide variety of species, particularly rodents. Infection is asymptomatic or mild …

Microbiota-dependent indole production stimulates the development of collagen-induced arthritis in mice

BJ Seymour, B Trent, BE Allen… - The Journal of …, 2024 - Am Soc Clin Investig
Altered tryptophan catabolism has been identified in inflammatory diseases like rheumatoid
arthritis (RA) and spondyloarthritis (SpA), but the causal mechanisms linking tryptophan …

One or two injections of MVA-vectored vaccine shields hACE2 transgenic mice from SARS-CoV-2 upper and lower respiratory tract infection

R Liu, JL Americo, CA Cotter, PL Earl… - Proceedings of the …, 2021 - National Acad Sciences
Modified vaccinia virus Ankara (MVA) is a replication-restricted smallpox vaccine, and
numerous clinical studies of recombinant MVAs (rMVAs) as vectors for prevention of other …

Injectable, tough alginate cryogels as cancer vaccines

TY Shih, SO Blacklow, AW Li… - Advanced …, 2018 - Wiley Online Library
A covalently crosslinked methacrylated (MA)‐alginate cryogel vaccine has been previously
shown to generate a potent response against murine melanoma, but is not mechanically …

An engineered HIV-1 Gag-based VLP displaying high antigen density induces strong antibody-dependent functional immune responses

F Tarrés-Freixas, C Aguilar-Gurrieri… - npj Vaccines, 2023 - nature.com
Antigen display on the surface of Virus-Like Particles (VLPs) improves immunogenicity
compared to soluble proteins. We hypothesised that immune responses can be further …

An invariant Trypanosoma vivax vaccine antigen induces protective immunity

D Autheman, C Crosnier, S Clare, DA Goulding… - Nature, 2021 - nature.com
Trypanosomes are protozoan parasites that cause infectious diseases, including African
trypanosomiasis (sleeping sickness) in humans and nagana in economically important …

Systemic prime mucosal boost significantly increases protective efficacy of bivalent RSV influenza viral vectored vaccine

C Bissett, S Belij-Rammerstorfer, M Ulaszewska… - npj Vaccines, 2024 - nature.com
Although licensed vaccines against influenza virus have been successful in reducing
pathogen-mediated disease, they have been less effective at preventing viral infection of the …

Podocyte expression of human phospholipase A2 receptor 1 causes immune-mediated membranous nephropathy in mice

NM Tomas, S Dehde, C Meyer-Schwesinger… - Kidney international, 2023 - Elsevier
Antibody-mediated autoimmune pathologies like membranous nephropathy are difficult to
model, particularly in the absence of local target antigen expression in model organisms …

The classical pathway triggers pathogenic complement activation in membranous nephropathy

L Seifert, G Zahner, C Meyer-Schwesinger… - Nature …, 2023 - nature.com
Membranous nephropathy (MN) is an antibody-mediated autoimmune disease
characterized by glomerular immune complexes containing complement components …