Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide

D Krewski, RA Yokel, E Nieboer… - Journal of Toxicology …, 2007 - Taylor & Francis
Full article: Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium
Hydroxide Skip to Main Content Taylor and Francis Online homepage Taylor and Francis …

Mechanism of immunopotentiation and safety of aluminum adjuvants

H HogenEsch - Frontiers in immunology, 2013 - frontiersin.org
Aluminum-containing adjuvants are widely used in preventive vaccines against infectious
diseases and in preparations for allergy immunotherapy. The mechanism by which they …

Immunological mechanisms of allergen-specific immunotherapy

M Larché, CA Akdis, R Valenta - Nature Reviews Immunology, 2006 - nature.com
Allergen-specific immunotherapy has been carried out for almost a century and remains one
of the few antigen-specific treatments for inflammatory diseases. The mechanisms by which …

Toll-like receptor agonists as adjuvants for allergen immunotherapy

ME Kirtland, DC Tsitoura, SR Durham… - Frontiers in …, 2020 - frontiersin.org
Toll-like receptors (TLRs) are essential components of innate immunity and provide
defensive inflammatory responses to invading pathogens. Located within the plasma …

Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation

SL Hem, H HogenEsch - Expert review of vaccines, 2007 - Taylor & Francis
Aluminum-containing adjuvants are an important component of many vaccines because
they safely potentiate the immune response. The structure and properties of aluminum …

Allergic rhinitis and its impact on asthma update: allergen immunotherapy

G Passalacqua, SR Durham - Journal of Allergy and Clinical Immunology, 2007 - Elsevier
The Allergic Rhinitis and its Impact on Asthma document was first published in 2001. Since
then, new data on specific immunotherapy have appeared. This review is intended as an …

Use of A‐type CpG oligodeoxynucleotides as an adjuvant in allergen‐specific immunotherapy in humans: a phase I/IIa clinical trial

G Senti, P Johansen, S Haug, C Bull… - Clinical & …, 2009 - Wiley Online Library
Background B‐type CpG oligodeoxynucleotides (ODN) is currently used in clinical trials
because of its prolonged half–life, which is due to its phosphorothioate backbone. A‐type …

Immunotherapy for allergic rhinitis

SM Walker, SR Durham, SJ Till… - Clinical & …, 2011 - Wiley Online Library
Allergic rhinitis (AR) affects more than 20% of the population in the United Kingdom and
western Europe and represents a major cause of morbidity that includes interference with …

Activation of dendritic cells and induction of CD4+ T cell differentiation by aluminum-containing adjuvants

A Sokolovska, SL Hem, H HogenEsch - Vaccine, 2007 - Elsevier
Aluminum-containing adjuvants are widely used in licensed human and veterinary vaccines.
However, the mechanism by which these adjuvants enhance the immune response and …

New approaches to allergen immunotherapy

NC Gunawardana, SR Durham - Annals of Allergy, Asthma & Immunology, 2018 - Elsevier
Objective New insights into mechanisms should enable strategic improvement of allergen
immunotherapy, aiming to make it safer, faster, more effective, and able to induce long-term …