Various chemicals found in the human and wildlife environments have the potential to
disrupt endocrine functions in exposed organisms. Increasingly, the enzymes involved in the …

The 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase (3β-HSD) isoenzymes are
responsible for the oxidation and isomerization of Δ5-3β-hydroxysteroid precursors into Δ4 …

Primary aldosteronism, a common cause of severe hypertension, features constitutive
production of the adrenal steroid aldosterone. We analyzed a multiplex family with familial …

Obesity has become an epidemic problem in western societies, contributing to metabolic
diseases, hypertension, and cardiovascular disease. Overweight and obesity are frequently …

Various pesticides known or suspected to interfere with steroid hormone function were
screened in H295R cells for effects on catalytic activity and mRNA expression of aromatase …

There is increasing concern that certain chemicals in the environment can cause endocrine
disruption in exposed humans and wildlife. Investigations of potential effects on endocrine …

The role of cytochrome P450 17 alpha-hydroxylase and 3 beta-hydroxysteroid dehydrogenase in the
integration of gonadal and adrenal steroidogenesis via the delta 5 and delta 4 pathways of …

The human adrenal cortex is a complex endocrine organ that secretes mineralocorticoids,
glucocorticoids and adrenal androgens. These steroids arise from morphologically and …

Aldosterone, the primary human mineralocorticoid, is a major regulator of intravascular
volume and blood pressure. The capacity of the adrenal gland to produce aldosterone is …

Aldosterone is a steroid hormone synthesized in and secreted from the outer layer of the
adrenal cortex, the zona glomerulosa. Aldosterone is responsible for regulating sodium …