Recent advances in biological active sulfonamide based hybrid compounds part B: Two-component sulfonamide hybrids
Sulfonamide compounds, also known as sulfa drugs, are a significant class of synthetic
bacteriostatic antimicrobials and were the primary source of therapy against bacterial …
bacteriostatic antimicrobials and were the primary source of therapy against bacterial …
Alternative experimental models for studying influenza proteins, host–virus interactions and anti-influenza drugs
SCJH Chua, HQ Tan, D Engelberg, LHK Lim - Pharmaceuticals, 2019 - mdpi.com
Ninety years after the discovery of the virus causing the influenza disease, this malady
remains one of the biggest public health threats to mankind. Currently available drugs and …
remains one of the biggest public health threats to mankind. Currently available drugs and …
QSAR study of N-substituted oseltamivir derivatives as potent avian influenza virus H5N1 inhibitors using quantum chemical descriptors and statistical methods
In silico modelling studies were executed on thirty two N-substituted oseltamivir derivatives
as inhibitors of influenza virus H5N1. Robust validated quantitative structure–activity …
as inhibitors of influenza virus H5N1. Robust validated quantitative structure–activity …
In silico QSAR and molecular docking simulation of some novel aryl sulfonamide derivatives as inhibitors of H5N1 influenza A virus subtype
Background This research provides a comprehensive analysis of QSAR modeling
performed on 25 aryl sulfonamide derivatives to predict their effective concentration (EC 50) …
performed on 25 aryl sulfonamide derivatives to predict their effective concentration (EC 50) …
Discovery of aryl benzoyl hydrazide derivatives as novel potent broad-spectrum inhibitors of influenza A virus RNA-dependent RNA polymerase (RdRp)
X Liu, J Liang, Y Yu, X Han, L Yu, F Chen… - Journal of Medicinal …, 2022 - ACS Publications
Influenza A viruses possess a high antigenic shift, and the approved anti-influenza drugs are
extremely limited, which makes the development of novel anti-influenza drugs for the clinical …
extremely limited, which makes the development of novel anti-influenza drugs for the clinical …
Sinuscalide A: An Antiviral Norcembranoid with an 8/8-Fused Carbon Scaffold from the South China Sea Soft Coral Sinularia scabra
J Liu, Q Tang, J Huang, T Li, H Ouyang… - The Journal of …, 2022 - ACS Publications
Sinuscalide A (1), featuring an uncommon 8/8-fused carbon scaffold, three new
norditerpenes, sinuscalides B–D (2–4), and sinuscatone A (5), with a 5/4/9 tricyclic carbon …
norditerpenes, sinuscalides B–D (2–4), and sinuscatone A (5), with a 5/4/9 tricyclic carbon …
[HTML][HTML] Identification of a novel binding inhibitor that blocks the interaction between hSCARB2 and VP1 of enterovirus 71
Q Tang, Z Xu, F Zhang, Y Cai, Y Chen, B Lu, H Zhou… - Cell Insight, 2022 - Elsevier
Abstract Enterovirus 71 (EV-A71) infection causes severe hand-foot-and-mouth disease that
leads to cardiopulmonary complications and death in young children under 5 years of age …
leads to cardiopulmonary complications and death in young children under 5 years of age …
Acetylenic sulfones and acetylenic sulfonamide analogs: a novel and preferable antimicrobial drugs based on computational strategies
This study was done to report virtual screening and molecular docking studies of
sulfacetamide derivatives as new antimicrobial drugs, belonging to the pharmacological …
sulfacetamide derivatives as new antimicrobial drugs, belonging to the pharmacological …
Discovery and SAR research for antivirus activity of novel butenolide on influenza a virus H1N1 in vitro and in vivo
Z Wang, X Hu, Y Li, X Mou, C Wang, X Chen, Y Tan… - ACS …, 2019 - ACS Publications
Influenza viruses (IV) cause substantial morbidity and mortality through routine seasonal
spread and epidemics. A novel series of butenolides were discovered to be able to inhibit …
spread and epidemics. A novel series of butenolides were discovered to be able to inhibit …
Structure-aided optimization of 3-O-β-chacotriosyl ursolic acid as novel H5N1 entry inhibitors with high selective index
Currently, entry inhibitors contribute immensely in developing a new generation of anti-
influenza virus drugs. Our earlier studies have identified that 3-O-β-chacotriosyl ursolic acid …
influenza virus drugs. Our earlier studies have identified that 3-O-β-chacotriosyl ursolic acid …