Recent advances in biological active sulfonamide based hybrid compounds part B: Two-component sulfonamide hybrids

S Ghomashi, R Ghomashi, H Aghaei… - Current Medicinal …, 2023 - ingentaconnect.com
Sulfonamide compounds, also known as sulfa drugs, are a significant class of synthetic
bacteriostatic antimicrobials and were the primary source of therapy against bacterial …

Alternative experimental models for studying influenza proteins, host–virus interactions and anti-influenza drugs

SCJH Chua, HQ Tan, D Engelberg, LHK Lim - Pharmaceuticals, 2019 - mdpi.com
Ninety years after the discovery of the virus causing the influenza disease, this malady
remains one of the biggest public health threats to mankind. Currently available drugs and …

QSAR study of N-substituted oseltamivir derivatives as potent avian influenza virus H5N1 inhibitors using quantum chemical descriptors and statistical methods

S Chtita, A Aouidate, A Belhassan, A Ousaa… - New Journal of …, 2020 - pubs.rsc.org
In silico modelling studies were executed on thirty two N-substituted oseltamivir derivatives
as inhibitors of influenza virus H5N1. Robust validated quantitative structure–activity …

In silico QSAR and molecular docking simulation of some novel aryl sulfonamide derivatives as inhibitors of H5N1 influenza A virus subtype

M Abdullahi, GA Shallangwa, A Uzairu - Beni-Suef University Journal of …, 2020 - Springer
Background This research provides a comprehensive analysis of QSAR modeling
performed on 25 aryl sulfonamide derivatives to predict their effective concentration (EC 50) …

Discovery of aryl benzoyl hydrazide derivatives as novel potent broad-spectrum inhibitors of influenza A virus RNA-dependent RNA polymerase (RdRp)

X Liu, J Liang, Y Yu, X Han, L Yu, F Chen… - Journal of Medicinal …, 2022 - ACS Publications
Influenza A viruses possess a high antigenic shift, and the approved anti-influenza drugs are
extremely limited, which makes the development of novel anti-influenza drugs for the clinical …

Sinuscalide A: An Antiviral Norcembranoid with an 8/8-Fused Carbon Scaffold from the South China Sea Soft Coral Sinularia scabra

J Liu, Q Tang, J Huang, T Li, H Ouyang… - The Journal of …, 2022 - ACS Publications
Sinuscalide A (1), featuring an uncommon 8/8-fused carbon scaffold, three new
norditerpenes, sinuscalides B–D (2–4), and sinuscatone A (5), with a 5/4/9 tricyclic carbon …

[HTML][HTML] Identification of a novel binding inhibitor that blocks the interaction between hSCARB2 and VP1 of enterovirus 71

Q Tang, Z Xu, F Zhang, Y Cai, Y Chen, B Lu, H Zhou… - Cell Insight, 2022 - Elsevier
Abstract Enterovirus 71 (EV-A71) infection causes severe hand-foot-and-mouth disease that
leads to cardiopulmonary complications and death in young children under 5 years of age …

Acetylenic sulfones and acetylenic sulfonamide analogs: a novel and preferable antimicrobial drugs based on computational strategies

T Varani, M Abdouss, P Azerang… - Journal of …, 2022 - World Scientific
This study was done to report virtual screening and molecular docking studies of
sulfacetamide derivatives as new antimicrobial drugs, belonging to the pharmacological …

Discovery and SAR research for antivirus activity of novel butenolide on influenza a virus H1N1 in vitro and in vivo

Z Wang, X Hu, Y Li, X Mou, C Wang, X Chen, Y Tan… - ACS …, 2019 - ACS Publications
Influenza viruses (IV) cause substantial morbidity and mortality through routine seasonal
spread and epidemics. A novel series of butenolides were discovered to be able to inhibit …

Structure-aided optimization of 3-O-β-chacotriosyl ursolic acid as novel H5N1 entry inhibitors with high selective index

Y Liao, L Chen, S Li, Z Cui, Z Lei, H Li, S Liu… - Bioorganic & Medicinal …, 2019 - Elsevier
Currently, entry inhibitors contribute immensely in developing a new generation of anti-
influenza virus drugs. Our earlier studies have identified that 3-O-β-chacotriosyl ursolic acid …