[HTML][HTML] Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential

K Du, A Ramachandran, H Jaeschke - Redox biology, 2016 - Elsevier
Acetaminophen (APAP) hepatotoxicity is characterized by an extensive oxidative stress.
However, its source, pathophysiological role and possible therapeutic potential if targeted …

A review on the dietary flavonoid kaempferol

JM Calderon-Montano, E Burgos-Morón… - Mini reviews in …, 2011 - ingentaconnect.com
Epidemiological studies have revealed that a diet rich in plant-derived foods has a protective
effect on human health. Identifying bioactive dietary constituents is an active area of …

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity

H Jaeschke, MR McGill… - Drug metabolism …, 2012 - Taylor & Francis
Hepatotoxicity is a serious problem during drug development and for the use of many
established drugs. For example, acetaminophen overdose is currently the most frequent …

Therapeutic potential of plants and plant derived phytochemicals against acetaminophen-induced liver injury

SB Subramanya, B Venkataraman… - International journal of …, 2018 - mdpi.com
Acetaminophen (APAP), which is also known as paracetamol or N-acetyl-p-aminophenol is
a safe and potent drug for fever, pain and inflammation when used at its normal therapeutic …

Current issues with acetaminophen hepatotoxicity—a clinically relevant model to test the efficacy of natural products

H Jaeschke, MR McGill, CD Williams… - Life sciences, 2011 - Elsevier
There is a significant need to evaluate the therapeutic potential of natural products and other
compounds purported to be hepatoprotective. Acetaminophen-induced liver injury …

A Review on Cistus sp.: Phytochemical and Antimicrobial Activities

I Zalegh, M Akssira, M Bourhia, F Mellouki, N Rhallabi… - Plants, 2021 - mdpi.com
Resistance to drugs is reaching alarming levels and is placing human health at risk. With the
lack of new antimicrobials drugs, infectious diseases are becoming harder to treat. Hence …

Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products

H Jaeschke, CD Williams, MR McGill, Y Xie… - Food and Chemical …, 2013 - Elsevier
Extracts from medicinal plants, many of which have been used for centuries, are increasingly
tested in models of hepatotoxicity. One of the most popular models to evaluate the …

Genus Cistus: a model for exploring labdane-type diterpenes' biosynthesis and a natural source of high value products with biological, aromatic, and pharmacological …

D Papaefthimiou, A Papanikolaou, V Falara… - Frontiers in …, 2014 - frontiersin.org
The family Cistaceae (Angiosperm, Malvales) consists of 8 genera and 180 species, with 5
genera native to the Mediterranean area (Cistus, Fumara, Halimium, Helianthemum, and …

The effects of royal jelly on liver damage induced by paracetamol in mice

M Kanbur, G Eraslan, L Beyaz, S Silici… - Experimental and …, 2009 - Elsevier
The present study was undertaken to investigate the protective effect of royal jelly against
paracetamol-induced liver damage. The study was conducted in 90 female Swiss Albino …

[HTML][HTML] A review on hepatoprotective and immunomodulatory herbal plants

U Ilyas, DP Katare, V Aeri, PP Naseef - Pharmacognosy reviews, 2016 - ncbi.nlm.nih.gov
The liver is the most important organ that plays an important role in maintaining various
physiological processes in the body. Hepatitis is an inflammation of the liver and is …