Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer. NEPC arises
de novo only rarely; the disease predominantly develops from adenocarcinoma in response …

Owing to the development of multiple novel therapies, there has been major progress in the
treatment of advanced prostate cancer over the last two decades; however, the disease …

Epigenetic processes govern prostate cancer (PCa) biology, as evidenced by the
dependency of PCa cells on the androgen receptor (AR), a prostate master transcription …

Prostate cancer is the second most common cancer in men worldwide. Over the past
decade, large-scale integrative genomics efforts have enhanced our understanding of this …

Forkhead box (Fox) transcription factors are evolutionarily conserved in organisms ranging
from yeast to humans. They regulate diverse biological processes both during development …

Prostate cancer is the second most common cancer in men worldwide and causes over
250,000 deaths each year. Overtreatment of indolent disease also results in significant …

Abstract Characterization of the prostate cancer transcriptome and genome has identified
chromosomal rearrangements and copy number gains and losses, including ETS gene …

Forkhead box (FOX) proteins are multifaceted transcription factors that are responsible for
fine-tuning the spatial and temporal expression of a broad range of genes both during …

Mammalian genomes are populated with thousands of transcriptional enhancers that
orchestrate cell-type-specific gene expression programs,,,, but how those enhancers are …

Dysregulation of histone lysine methyltransferases and demethylases is one of the major
mechanisms driving the epigenetic reprogramming of transcriptional networks in castration …