Acute anterior uveitis and HLA-B27

JH Chang, PJ McCluskey, D Wakefield - Survey of ophthalmology, 2005 - Elsevier
Acute anterior uveitis is the most common form of uveitis. HLA-B27-associated acute anterior
uveitis is a distinct clinical entity that has wide-ranging medical significance due to its ocular …

Oral tolerance: immune mechanisms and treatment of autoimmune diseases

HL Weiner - Immunology today, 1997 - cell.com
Orally administered proteins induce systemic hyporesponsiveness to the fed protein. The
mechanism underlying such 'oral tolerance'depends on the amount of antigen fed. with …

Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis

Y Chen, VK Kuchroo, J Inobe, DA Hafler, HL Weiner - Science, 1994 - science.org
Experimental autoimmune encephalomyelitis (EAE) is a cell-mediated autoimmune disease
that serves as an animal model for multiple sclerosis. Oral administration of myelin basic …

Modulating immune responses with probiotic bacteria

T Matsuzaki, J Chin - Immunology and cell biology, 2000 - Wiley Online Library
For many years, probiotic bacteria have been known to confer health benefits to the
consumer. One possible mechanism for this may be the ability of probiotic bacteria to …

Induction of anergy or active suppression following oral tolerance is determined by antigen dosage.

A Friedman, HL Weiner - Proceedings of the National …, 1994 - National Acad Sciences
Oral tolerance was generated to hen egg white lysozyme in the mouse or to guinea pig
myelin basic protein in the rat by a low-dose (1 mg) or a high-dose (5-20 mg) feeding …

A protocol for oral desensitization in children with IgE‐mediated cow's milk allergy

P Meglio, E Bartone, M Plantamura, E Arabito… - Allergy, 2004 - Wiley Online Library
Objectives: To desensitize children with severe immunoglobulin (Ig) E‐mediated cow's milk
allergy in a period of 6 months by introducing increasing daily doses of cow's milk (CM) in …

" Tolerosomes" are produced by intestinal epithelial cells

M Karlsson, S Lundin, U Dahlgren… - European journal of …, 2001 - Wiley Online Library
The development of immunological tolerance to orally fed antigens depends on the
sampling, processing and transportation events followed in the intestinal epithelium. We …

Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis

R Martin, HF McFarland, JM Boggs - Critical reviews in clinical …, 1995 - Taylor & Francis
Multiple sclerosis (MS) is the most frequent, demyelinating disease of the central nervous
system (CNS) in Northern Europeans and North Americans. Despite intensive research its …

Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance.

MF Neurath, I Fuss, BL Kelsall, DH Presky… - The Journal of …, 1996 - rupress.org
In previous studies we showed that a chronic colitis associated with a Th1 T cell response
can be induced by the rectal administration of the haptenizing reagent 2, 4, 6-trinitrobenzene …

Nasal administration of amyloid‐β peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease

HL Weiner, CA Lemere, R Maron… - Annals of Neurology …, 2000 - Wiley Online Library
Progressive cerebral deposition of amyloid‐β (Aβ) peptide, an early and essential feature of
Alzheimer's disease (AD), is accompanied by an inflammatory reaction marked by …