Colorectal cancer (CRC) exhibits differences in incidence, pathogenesis, molecular
pathways and outcome depending on the location of the tumor. This review focuses on the …

Colorectal cancer (CRC) is a very heterogeneous disease that is caused by the interaction
of genetic and environmental factors. CRC develops through a gradual accumulation of …

To understand the genetic drivers of immune recognition and evasion in colorectal cancer,
we analyzed 1,211 colorectal cancer primary tumor samples, including 179 classified as …

Importance Evidence indicates a complex link between gut microbiome, immunity, and
intestinal tumorigenesis. To target the microbiota and immunity for colorectal cancer …

Background & Aims Evidence supports a carcinogenic role of Escherichia coli carrying the
pks island that encodes enzymes for colibactin biosynthesis. We hypothesized that the …

This review gives an account of recent advances in our knowledge of the molecular
mechanisms in colorectal cancer. Genetic changes in the germ line, combined with somatic …

Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. It results from an
accumulation of genetic and epigenetic changes in colon epithelial cells, which transforms …

Abstract The American Joint Committee on Cancer/Union Internationale Contre le Cancer
(AJCC/UICC) TNM staging system provides the most reliable guidelines for the routine …

Objective Colorectal cancer is typically classified into proximal colon, distal colon and rectal
cancer. Tumour genetic and epigenetic features differ by tumour location. Considering a …

BRAF mutation in colorectal cancer is associated with microsatellite instability (MSI) through
its relationship with high-level CpG island methylator phenotype (CIMP) and MLH1 promoter …