Kinetochores are molecular machines that power chromosome segregation during the
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …

BACKGROUND Meiotic chromosome segregation in human oocytes is notoriously error-
prone, especially with ageing. Such errors markedly reduce the reproductive chances of …

Meiosis is critically different from mitosis in that during meiosis, pairing and segregation of
homologous chromosomes occur. During meiosis, the morphology of sister chromatids …

To generate haploid gametes, germ cells undergo two consecutive meiotic divisions
requiring key changes to the cell division machinery. Here, we demonstrate that the …

Faithful chromosome segregation in mitosis and meiosis requires that chromosomes
properly attach to spindle microtubules. Initial kinetochore-microtubule attachments are often …

When eukaryotic cells enter mitosis, dispersed chromosomes move to the cell center along
microtubules to form a metaphase plate which facilitates the accurate chromosome …

Meiosis produces gametes through a specialized, two-step cell division, which is highly error
prone in humans. Reductional meiosis I, where maternal and paternal chromosomes …

Meiosis is a specialized style of cell division conserved in eukaryotes, particularly designed
for the production of gametes. A huge number of studies to date have demonstrated how …

The conserved meiosis-specific kinetochore regulator, meikin (Moa1 in fission yeast) plays a
central role in establishing meiosis-specific kinetochore function. However, the underlying …

Sister centromere fusion is a process unique to meiosis that promotes co-orientation of the
sister kinetochores, ensuring they attach to microtubules from the same pole during …