Targeting cardiac fibrosis in heart failure with preserved ejection fraction: mirage or miracle?
Cardiac fibrosis is central to the pathology of heart failure, particularly heart failure with
preserved ejection fraction (HF p EF). Irrespective of the underlying profibrotic condition (eg …
preserved ejection fraction (HF p EF). Irrespective of the underlying profibrotic condition (eg …
Hiding in plain sight: interleukin-11 emerges as a master regulator of fibrosis, tissue integrity, and stromal inflammation
Interleukin (IL)-11 is upregulated in a wide variety of fibro-inflammatory diseases such as
systemic sclerosis, rheumatoid arthritis, pulmonary fibrosis, inflammatory bowel disease …
systemic sclerosis, rheumatoid arthritis, pulmonary fibrosis, inflammatory bowel disease …
Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH
J Dong, S Viswanathan, E Adami, BK Singh… - Nature …, 2021 - nature.com
IL11 is important for fibrosis in non-alcoholic steatohepatitis (NASH) but its role beyond the
stroma in liver disease is unclear. Here, we investigate the role of IL11 in hepatocyte …
stroma in liver disease is unclear. Here, we investigate the role of IL11 in hepatocyte …
Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway
Abstract Interleukin (IL)-11 evolved as part of the innate immune response. In the human
lung, IL-11 upregulation has been associated with viral infections and a range of …
lung, IL-11 upregulation has been associated with viral infections and a range of …
IL‐11 in cardiac and renal fibrosis: late to the party but a central player
Fibrosis is a pathophysiological hallmark of cardiorenal disease. In the heart, fibrosis leads
to contractile dysfunction and arrhythmias; in the kidney, it is the final common pathway for …
to contractile dysfunction and arrhythmias; in the kidney, it is the final common pathway for …
IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts
Abstract Objectives Interleukin 11 (IL11) is highly upregulated in skin and lung fibroblasts
from patients with systemic sclerosis (SSc). Here we tested whether IL11 is mechanistically …
from patients with systemic sclerosis (SSc). Here we tested whether IL11 is mechanistically …
Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice
Interleukin 11 (IL11) is a profibrotic cytokine, secreted by myofibroblasts and damaged
epithelial cells. Smooth muscle cells (SMCs) also secrete IL11 under pathological conditions …
epithelial cells. Smooth muscle cells (SMCs) also secrete IL11 under pathological conditions …
Therapeutic targeting of IL-11 for chronic lung disease
RK Kortekaas, JK Burgess, R van Orsoy… - Trends in …, 2021 - cell.com
Interleukin (IL)-11 was originally recognized as an immunomodulatory and hematopoiesis-
inducing cytokine. However, although IL-11 is typically not found in healthy individuals, it is …
inducing cytokine. However, although IL-11 is typically not found in healthy individuals, it is …
Critical Conditions for Studying Interleukin‐11 Signaling In Vitro and Avoiding Experimental Artefacts
Interleukin (IL) 11 is a member of the IL6 family of cytokines which require the ubiquitous
gp130 receptor to activate canonical (JAK/STAT) and non‐canonical (eg, ERK) signaling …
gp130 receptor to activate canonical (JAK/STAT) and non‐canonical (eg, ERK) signaling …
Lung epithelial progenitor responses in diseased micro-environments
R Kortekaas - 2024 - research.rug.nl
Idiopathic pulmonary fibrosis (IPF) and chronic obstructive lung disease (COPD) are both
incurable lung diseases that worsen over time. The epithelium, which lines the inner surface …
incurable lung diseases that worsen over time. The epithelium, which lines the inner surface …