Cytokines and chemokines as mediators of prostate cancer metastasis

TO Adekoya, RM Richardson - International journal of molecular sciences, 2020 - mdpi.com
The consequences of prostate cancer metastasis remain severe, with huge impact on the
mortality and overall quality of life of affected patients. Despite the convoluted interplay and …

Angiogenesis and anti-angiogenic treatment in prostate cancer: mechanisms of action and molecular targets

E Ioannidou, M Moschetta, S Shah, JS Parker… - International journal of …, 2021 - mdpi.com
Prostate cancer (PC) is the most common cancer in men and the second leading cause of
cancer-related death worldwide. Many therapeutic advances over the last two decades have …

Discovery of thieno [2, 3-d] pyrimidine-based derivatives as potent VEGFR-2 kinase inhibitors and anti-cancer agents

SA El-Metwally, MM Abou-El-Regal, IH Eissa… - Bioorganic …, 2021 - Elsevier
Vascular endothelial growth factor-2 (VEGFR-2) is considered one of the most important
factors in tumor angiogenesis, and consequently a number of anticancer therapeutics have …

Randomized, double-blind, placebo-controlled phase III trial comparing docetaxel and prednisone with or without bevacizumab in men with metastatic castration …

WK Kelly, S Halabi, M Carducci, D George… - Journal of Clinical …, 2012 - ascopubs.org
Purpose A randomized, placebo-controlled study based on preclinical and clinical data that
supports the potential role of vascular endothelial growth factor in prostate cancer was …

Clinical implications of circulating angiogenic factors in cancer patients

RTP Poon, ST Fan, J Wong - Journal of Clinical Oncology, 2001 - ascopubs.org
PURPOSE: Angiogenesis, a process fundamental to tumor growth, is regulated by
angiogenic factors. This article reviews prognostic and other clinical implications of …

Blockade of NF-κB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis

S Huang, CA Pettaway, H Uehara, CD Bucana… - Oncogene, 2001 - nature.com
Since the NF-κB/relA transcription factor is constitutively activated in human prostate cancer
cells, we determined whether blocking NF-κB/relA activity in human prostate cancer cells …

A common 936 C/T mutation in the gene for vascular endothelial growth factor is associated with vascular endothelial growth factor plasma levels

W Renner, S Kotschan, C Hoffmann… - Journal of vascular …, 2000 - karger.com
Background: Vascular endothelial growth factor (VEGF) is an important regulator of
angiogenesis. Strong interindividual variations of VEGF plasma levels have been reported …

Targeting angiogenesis in prostate cancer

Z Melegh, S Oltean - International journal of molecular sciences, 2019 - mdpi.com
Prostate cancer is the most commonly diagnosed cancer among men in the Western world.
Although localized disease can be effectively treated with established surgical and …

Vascular endothelial growth factor (VEGF) in breast cancer: comparison of plasma, serum, and tissue VEGF and microvessel density and effects of tamoxifen

J Adams, PJ Carder, S Downey, MA Forbes… - Cancer research, 2000 - AACR
The assessment of angiogenesis in breast cancer is of importance as a key indicator of
survival and response to therapy. Circulating vascular endothelial growth factor (VEGF) …

Obesity and prostate cancer—microenvironmental roles of adipose tissue

A Saha, MG Kolonin, J DiGiovanni - Nature Reviews Urology, 2023 - nature.com
Obesity is known to have important roles in driving prostate cancer aggressiveness and
increased mortality. Multiple mechanisms have been postulated for these clinical …