Bitter-tasting drugs tune GDF15 and GLP-1 expression via bitter taste or motilin receptors in the intestine of patients with obesity

Q Wang, M Farhadipour, T Thijs, ER Sosoranga… - Molecular …, 2024 - Elsevier
Objective Growth differentiation factor 15 (GDF15), a stress related cytokine, was recently
identified as a novel satiety signal acting via the GFRAL receptor located in the hindbrain …

[HTML][HTML] GDF15 enhances anoikis resistance and metastasis of gastric cancer through protective autophagy

X Gao, Z Zhang, Q Li, G Tai, ZD Wang - Cellular Signalling, 2024 - Elsevier
Distant metastasis is a prevalent cause of mortality in gastric cancer (GC) patients. Anoikis, a
process that induces cell death when cells get detached from the extracellular matrix (ECM) …

Leveraging Microbiome Composition Variability for Precision Medicine in Idiopathic Pulmonary Fibrosis

H Fujimoto, CN D'Alessandro-Gabazza… - American journal of …, 2024 - atsjournals.org
We read with great interest the recent article by Oldham et al. published recently in the
Journal (1). The study conducted by the authors represents a significant leap forward in our …