Circadian rhythm as a therapeutic target
The circadian clock evolved in diverse organisms to integrate external environmental
changes and internal physiology. The clock endows the host with temporal precision and …
changes and internal physiology. The clock endows the host with temporal precision and …
Mechanisms and function of substrate recruitment by F-box proteins
S phase kinase-associated protein 1 (SKP1)–cullin 1 (CUL1)–F-box protein (SCF) ubiquitin
ligase complexes use a family of F-box proteins as substrate adaptors to mediate the …
ligase complexes use a family of F-box proteins as substrate adaptors to mediate the …
Molecular mechanism of the repressive phase of the mammalian circadian clock
The mammalian circadian clock consists of a transcription–translation feedback loop (TTFL)
composed of CLOCK–BMAL1 transcriptional activators and CRY–PER transcriptional …
composed of CLOCK–BMAL1 transcriptional activators and CRY–PER transcriptional …
Macromolecular assemblies of the mammalian circadian clock
The mammalian circadian clock is built on a feedback loop in which PER and CRY proteins
repress their own transcription. We found that in mouse liver nuclei all three PERs, both …
repress their own transcription. We found that in mouse liver nuclei all three PERs, both …
Genetics of circadian rhythms in Mammalian model organisms
PL Lowrey, JS Takahashi - Advances in genetics, 2011 - Elsevier
The mammalian circadian system is a complex hierarchical temporal network which is
organized around an ensemble of uniquely coupled cells comprising the principal circadian …
organized around an ensemble of uniquely coupled cells comprising the principal circadian …
Regulating the suprachiasmatic nucleus (SCN) circadian clockwork: interplay between cell-autonomous and circuit-level mechanisms
ED Herzog, T Hermanstyne… - Cold Spring …, 2017 - cshperspectives.cshlp.org
The suprachiasmatic nucleus (SCN) is the principal circadian clock of the brain, directing
daily cycles of behavior and physiology. SCN neurons contain a cell-autonomous …
daily cycles of behavior and physiology. SCN neurons contain a cell-autonomous …
Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis
B Schittek, T Sinnberg - Molecular cancer, 2014 - Springer
Isoforms of the casein kinase 1 (CK1) family have been shown to phosphorylate key
regulatory molecules involved in cell cycle, transcription and translation, the structure of the …
regulatory molecules involved in cell cycle, transcription and translation, the structure of the …
The CK1 family: contribution to cellular stress response and its role in carcinogenesis
U Knippschild, M Krüger, J Richter, P Xu… - Frontiers in …, 2014 - frontiersin.org
Members of the highly conserved and ubiquitously expressed pleiotropic CK1 family play
major regulatory roles in many cellular processes including DNA-processing and repair …
major regulatory roles in many cellular processes including DNA-processing and repair …
[图书][B] Circadian physiology
R Refinetti - 2016 - books.google.com
Circadian rhythms influence most of our life activities, notably getting up and going to sleep
every day. The new edition of this book delves into the mechanisms surrounding how these …
every day. The new edition of this book delves into the mechanisms surrounding how these …
[HTML][HTML] The phosphorylation switch that regulates ticking of the circadian clock
R Narasimamurthy, DM Virshup - Molecular cell, 2021 - cell.com
Summary In our 24/7 well-lit world, it's easy to skip or delay sleep to work, study, and play.
However, our circadian rhythms are not easily fooled; the consequences of jet lag and shift …
However, our circadian rhythms are not easily fooled; the consequences of jet lag and shift …