Prodrugs as empowering tools in drug discovery and development: recent strategic applications of drug delivery solutions to mitigate challenges associated with lead …
MAM Subbaiah, J Rautio, NA Meanwell - Chemical Society Reviews, 2024 - pubs.rsc.org
The delivery of a drug to a specific organ or tissue at an efficacious concentration is the
pharmacokinetic (PK) hallmark of promoting effective pharmacological action at a target site …
pharmacokinetic (PK) hallmark of promoting effective pharmacological action at a target site …
[HTML][HTML] Prodrug therapies for infectious and neurodegenerative diseases
Prodrugs are bioreversible drug derivatives which are metabolized into a pharmacologically
active drug following chemical or enzymatic modification. This approach is designed to …
active drug following chemical or enzymatic modification. This approach is designed to …
[HTML][HTML] Molecular factors and pathways of hepatotoxicity associated with HIV/SARS-CoV-2 protease inhibitors
C Ji - International Journal of Molecular Sciences, 2023 - mdpi.com
Antiviral protease inhibitors are peptidomimetic molecules that block the active catalytic
center of viral proteases and, thereby, prevent the cleavage of viral polyprotein precursors …
center of viral proteases and, thereby, prevent the cleavage of viral polyprotein precursors …
Improving Drug Delivery While Tailoring Prodrug Activation to Modulate Cmax and Cmin by Optimization of (Carbonyl)oxyalkyl Linker-Based Prodrugs of …
M AM Subbaiah, L Subramani, T Ramar… - Journal of Medicinal …, 2022 - ACS Publications
Structure–property relationships associated with a series of (carbonyl) oxyalkyl amino acid
ester prodrugs of the marketed HIV-1 protease inhibitor atazanavir (1), designed to enhance …
ester prodrugs of the marketed HIV-1 protease inhibitor atazanavir (1), designed to enhance …
Antiviral and antiretroviral prodrugs
L Pisano, CT Supuran - Advances in Prodrugs, 2025 - Elsevier
A range of widely used antivirals are prodrugs or double prodrugs, being extensively
transformed prior to exerting their full pharmacologic activity. They include the DNA …
transformed prior to exerting their full pharmacologic activity. They include the DNA …
Inhalable Prodrugs for Pulmonary Therapeutics
PP Mehta, V Dhapte-Pawar - Pulmonary Drug Delivery Systems: Material …, 2023 - Springer
Like the liver's major metabolic organ, pulmonary airways contain many potential
metabolizing enzymes and metabolic pathways. Notably, the pulmonary metabolic network …
metabolizing enzymes and metabolic pathways. Notably, the pulmonary metabolic network …
[PDF][PDF] J. Edagwa, B.; Mosley, RL; Gendelman, HE Prodrug Therapies for Infectious and Neurodegenerative Diseases. Pharmaceutics 2022, 14, 518
Prodrugs are bioreversible drug derivatives which are metabolized into a pharmacologically
active drug following chemical or enzymatic modification. This approach is designed to …
active drug following chemical or enzymatic modification. This approach is designed to …