The fiber g-ratio is the ratio of the inner to the outer diameter of the myelin sheath of a
myelinated axon. It has a limited dynamic range in healthy white matter, as it is optimized for …

Quantitative magnetic resonance imaging can be combined with advanced biophysical
models to measure microstructural features of white matter. Non-invasive microstructural …

Non-invasive estimation of brain microstructure features using diffusion MRI (dMRI)—known
as Microstructure Imaging—has become an increasingly diverse and complicated field over …

Segmenting axon and myelin from microscopic images is relevant for studying the
peripheral and central nervous system and for validating new MRI techniques that aim at …

The estimation of the apparent axon diameter (AAD) via diffusion MRI is affected by the
incoherent alignment of single axons around its axon bundle direction, also known as …

Conventional magnetic resonance imaging (MRI) systems are not measurement devices.
Clinical MRI relies on visual assessment of images represented on an arbitrary grayscale …

We propose to validate the PICASO (Precise Inference and Characterization of Structural
Organization) 1 biophysical model of tissue microstructure using a full-slice histology of cat …

Cancer is the leading cause of death globally; ahead of heart disease, stroke and chronic
obstructive pulmonary disease. There were 8.2 million attributed deaths in 2012 [1], and the …

A microstructure fingerprinting approach is proposed in which an optimal single-fascicle
configuration is selected from a pre-computed collection of Monte Carlo diffusion signals, or …

This study is the first attempt towards histological validation of three advanced diffusion MRI
measures derived from the 3D diffusion propagator in white matter tissue: i) return-to-origin …