Heat shock proteins: Biological functions, pathological roles, and therapeutic opportunities
The heat shock proteins (HSPs) are ubiquitous and conserved protein families in both
prokaryotic and eukaryotic organisms, and they maintain cellular proteostasis and protect …
prokaryotic and eukaryotic organisms, and they maintain cellular proteostasis and protect …
Infections, atherosclerosis, and coronary heart disease
Atherosclerosis is a chronic inflammatory disease. Pathophysiological similarities between
chronic infections and atherosclerosis triggered interest in a clinical association between …
chronic infections and atherosclerosis triggered interest in a clinical association between …
Mitochondrial dysfunction in vascular endothelial cells and its role in atherosclerosis
K Qu, F Yan, X Qin, K Zhang, W He, M Dong… - Frontiers in …, 2022 - frontiersin.org
The mitochondria are essential organelles that generate large amounts of ATP via the
electron transport chain (ECT). Mitochondrial dysfunction causes reactive oxygen species …
electron transport chain (ECT). Mitochondrial dysfunction causes reactive oxygen species …
Cytokines in atherosclerosis: pathogenic and regulatory pathways
A Tedgui, Z Mallat - Physiological reviews, 2006 - journals.physiology.org
Atherosclerosis is a chronic disease of the arterial wall where both innate and adaptive
immunoinflammatory mechanisms are involved. Inflammation is central at all stages of …
immunoinflammatory mechanisms are involved. Inflammation is central at all stages of …
Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors
KL Becker, ES Nylen, JC White, B Muller… - The Journal of …, 2004 - academic.oup.com
Calcitonin (CT) is a hormone that received its name because of its secretion in response to
induced hypercalcemia and its hypocalcemic effect (1). It was shown to originate from the …
induced hypercalcemia and its hypocalcemic effect (1). It was shown to originate from the …
Heat shock proteins as regulators of the immune response
AG Pockley - The lancet, 2003 - thelancet.com
Until recently, heat shock proteins (also known as heat stress proteins) have mostly been
regarded as intracellular molecules that mediate a range of essential housekeeping and …
regarded as intracellular molecules that mediate a range of essential housekeeping and …
Inflammation and infections as risk factors for ischemic stroke
PJ Lindsberg, AJ Grau - Stroke, 2003 - Am Heart Assoc
Background—Inflammatory processes have fundamental roles in stroke in both the etiology
of ischemic cerebrovascular disease and the pathophysiology of cerebral ischemia. We …
of ischemic cerebrovascular disease and the pathophysiology of cerebral ischemia. We …
Atherosclerosis as an inflammatory disease
A Tuttolomondo, D Di Raimondo… - Current …, 2012 - ingentaconnect.com
In many ways, atherosclerosis is a chronic inflammatory disorder and this issue is confirmed
by recent investigations of that have focused on inflammation, providing new insight into …
by recent investigations of that have focused on inflammation, providing new insight into …
Heat shock proteins and immune system
MF Tsan, B Gao - Journal of Leucocyte Biology, 2009 - academic.oup.com
Heat shock proteins (HSPs) such as HSP 60 (Hsp60), Hsp70, Hsp90, and gp96, have been
reported to play important roles in antigen presentation and cross-presentation, activation of …
reported to play important roles in antigen presentation and cross-presentation, activation of …
Chronic infections and the risk of carotid atherosclerosis: prospective results from a large population study
Background—Chronic infections have been implicated in the pathogenesis of
atherosclerosis, yet from an epidemiological perspective, this concept remains controversial …
atherosclerosis, yet from an epidemiological perspective, this concept remains controversial …