Heat shock proteins: Biological functions, pathological roles, and therapeutic opportunities

C Hu, J Yang, Z Qi, H Wu, B Wang, F Zou, H Mei… - MedComm, 2022 - Wiley Online Library
The heat shock proteins (HSPs) are ubiquitous and conserved protein families in both
prokaryotic and eukaryotic organisms, and they maintain cellular proteostasis and protect …

Infections, atherosclerosis, and coronary heart disease

NVK Pothineni, S Subramany, K Kuriakose… - European heart …, 2017 - academic.oup.com
Atherosclerosis is a chronic inflammatory disease. Pathophysiological similarities between
chronic infections and atherosclerosis triggered interest in a clinical association between …

Mitochondrial dysfunction in vascular endothelial cells and its role in atherosclerosis

K Qu, F Yan, X Qin, K Zhang, W He, M Dong… - Frontiers in …, 2022 - frontiersin.org
The mitochondria are essential organelles that generate large amounts of ATP via the
electron transport chain (ECT). Mitochondrial dysfunction causes reactive oxygen species …

Cytokines in atherosclerosis: pathogenic and regulatory pathways

A Tedgui, Z Mallat - Physiological reviews, 2006 - journals.physiology.org
Atherosclerosis is a chronic disease of the arterial wall where both innate and adaptive
immunoinflammatory mechanisms are involved. Inflammation is central at all stages of …

Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors

KL Becker, ES Nylen, JC White, B Muller… - The Journal of …, 2004 - academic.oup.com
Calcitonin (CT) is a hormone that received its name because of its secretion in response to
induced hypercalcemia and its hypocalcemic effect (1). It was shown to originate from the …

Heat shock proteins as regulators of the immune response

AG Pockley - The lancet, 2003 - thelancet.com
Until recently, heat shock proteins (also known as heat stress proteins) have mostly been
regarded as intracellular molecules that mediate a range of essential housekeeping and …

Inflammation and infections as risk factors for ischemic stroke

PJ Lindsberg, AJ Grau - Stroke, 2003 - Am Heart Assoc
Background—Inflammatory processes have fundamental roles in stroke in both the etiology
of ischemic cerebrovascular disease and the pathophysiology of cerebral ischemia. We …

Atherosclerosis as an inflammatory disease

A Tuttolomondo, D Di Raimondo… - Current …, 2012 - ingentaconnect.com
In many ways, atherosclerosis is a chronic inflammatory disorder and this issue is confirmed
by recent investigations of that have focused on inflammation, providing new insight into …

Heat shock proteins and immune system

MF Tsan, B Gao - Journal of Leucocyte Biology, 2009 - academic.oup.com
Heat shock proteins (HSPs) such as HSP 60 (Hsp60), Hsp70, Hsp90, and gp96, have been
reported to play important roles in antigen presentation and cross-presentation, activation of …

Chronic infections and the risk of carotid atherosclerosis: prospective results from a large population study

S Kiechl, G Egger, M Mayr, CJ Wiedermann, E Bonora… - Circulation, 2001 - Am Heart Assoc
Background—Chronic infections have been implicated in the pathogenesis of
atherosclerosis, yet from an epidemiological perspective, this concept remains controversial …