Diabetes mellitus has profound effects on multiple organ systems; however, the loss of
vision caused by diabetic retinopathy might be one of the most impactful in a patient's life …

Diabetes adversely affects multiple organs, including the kidney, eye and nerve, leading to
diabetic kidney disease, diabetic retinopathy and diabetic neuropathy, respectively. In both …

Diabetes causes a number of metabolic and physiologic abnormalities in the retina, but
which of these abnormalities contribute to recognized features of diabetic retinopathy (DR) is …

In mammalian cells, elongases and desaturases play critical roles in regulating the length
and degree of unsaturation of fatty acids and thereby their functions and metabolic fates. In …

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection. In sepsis, a complicated immune response is initiated, which varies over time with …

The retinal pigment epithelium-photoreceptor interphase is renewed each day in a stunning
display of cellular interdependence. While photoreceptors use photosensitive pigments to …

Most diabetes researchers and clinicians are aware of the major advances made in
understanding the pathobiology of proliferative diabetic retinopathy. However mechanisms …

Diabetic retinopathy (DR) impairs vision of patients with type 1 and type 2 diabetes,
associated with vascular dysfunction and occlusion, retinal edema, hemorrhage, and …

Purpose To relate the concept of the retinal neurovascular unit and its alterations in diabetes
to the pathophysiology of diabetic retinopathy. Methods Case illustrations and conceptual …

Lipid metabolic abnormalities have emerged as potential risk factors for the development
and progression of diabetic complications, including diabetic retinopathy (DR). This review …