Disruption of cerebral iron regulation appears to have a role in aging and in the
pathogenesis of various neurodegenerative disorders. Possible unfavorable impacts of iron …

Iron chelation has been introduced as a new therapeutic concept for the treatment of
neurodegenerative diseases with features of iron overload. At difference with iron chelators …

Our understanding of the syndromes of Neurodegeneration with Brain Iron Accumulation
(NBIA) continues to grow considerably. In addition to the core syndromes of pantothenate …

Syndromes with neurodegeneration with brain iron accumulation (NBIA) are a group of
neurodegenerative disorders associated with abnormalities in brain iron metabolism and …

In parallel to recent developments of genetic techniques, understanding of the syndromes of
neurodegeneration with brain iron accumulation has grown considerably. The …

Regulation of iron metabolism is crucial: both iron deficiency and iron overload can cause
disease. In recent years, our understanding of the syndromes of Neurodegeneration with …

Introduction The purpose of this review was to summarize current applications of non-
contrast-enhanced quantitative magnetic resonance imaging (qMRI) in tissue differentiation …

This review gives an outline of the clinical presentations of recently discovered NBIA
syndromes and summarizes the clues to their differential diagnosis. While chelating …

Recent genetic findings have shed light on the role of iron, manganese, and copper in
neurodegenerative disease. MRI is a helpful diagnostic tool in the investigation of basal …

Pantothenate‐kinase–associated neurodegeneration (PKAN) is an autosomal recessive
disorder characterized by iron deposits in basal ganglia. The aim of this study was to …