Autophagy is a process that targets various intracellular elements for degradation.
Autophagy can be non-selective—associated with the indiscriminate engulfment of cytosolic …

Macroautophagy (hereafter called autophagy) is a highly conserved physiological process
that degrades over-abundant or damaged organelles, large protein aggregates and …

Selective autophagy is the lysosomal degradation of specific intracellular components
sequestered into autophagosomes, late endosomes, or lysosomes through the activity of …

Selective autophagy relies on soluble or membrane-bound cargo receptors that recognize
cargo and bring about autophagosome formation at the cargo. The cargo-bound receptors …

The clearance of surplus, broken, or dangerous components is key for maintaining cellular
homeostasis. The failure to remove protein aggregates, damaged organelles, or intracellular …

ER-phagy (reticulophagy) defines the degradation of portions of the endoplasmic reticulum
(ER) within lysosomes or vacuoles. It is part of the self-digestion (ie, autophagic) programs …

In selective autophagy, cytoplasmic components are selected and tagged before being
sequestered into an autophagosome by means of selective autophagy receptors such as …

Efforts to understand how mitochondrial dysfunction contributes to neurodegeneration have
primarily focussed on the role of mitochondria in neuronal energy metabolism. However …

Macroautophagy is an intracellular degradation system that delivers diverse cytoplasmic
materials to lysosomes via autophagosomes. Recent advances have enabled identification …

The selective clearance of organelles by autophagy is critical for the regulation of cellular
homeostasis in organisms from yeast to humans. Removal of damaged organelles clears …