Patients with sickle cell disease (SCD) display priapism, a prolonged penile erection in the
absence of sexual arousal. The current pharmacological treatments for SCD-associated …

Sickle cell disease is an inherited blood disorder afflicting an estimated 100,000 individuals
in the United States and over 20 million people worldwide. The disease is heralded as the …

Aims Maladaptive ventricular remodeling is a major cause of ventricular arrhythmias
following myocardial infarction (MI) and adversely impacts the quality of life of affected …

Background Inflammation in the central nervous system (CNS) is observed in many
neurological disorders. Nitric oxide-soluble guanylate cyclase-cyclic guanosine …

We characterized the human β-like globin transgenes in two mouse models of sickle cell
disease (SCD) and tested a genome-editing strategy to induce red blood cell fetal …

The root cause of sickle cell disease (SCD) has been known for nearly a century, however,
few therapies to treat the disease are available. Over several decades of work, with …

Background Although nitric oxide based therapeutics have been shown in preclinical
models to reduce vaso-occlusive events and improve cardiovascular function, a clinical trial …

Ischemia and reperfusion (IR) damage organs and contribute to many disease states. Few
effective treatments exist that attenuate IR injury. The augmentation of nitric oxide (NO) …

Soluble guanylate cyclase agonists and guanylate cyclase C agonists are two popular drugs
for diseases of the cardiovascular system and digestive systems. The common denominator …

Hydroxyurea (HU) is the key drug to treat Sickle cell anemia (SCA). However, its treatment is
associated with the liability of myelosuppression. The present study aimed to investigate the …