Mono-and polyunsaturated lipids are widely distributed in Nature, and are structurally and
functionally a diverse class of molecules with a variety of physicochemical, biological …

G protein-coupled receptors (GPCRs) are historically the most successful family of drug
targets. In recent times it has become clear that the pharmacology of these receptors is far …

Cancer is a significant global public health issue and, despite advancements in detection
and treatment, the prognosis remains poor. Cancer is a complex disease characterized by …

G protein-coupled receptors (GPCRs) remain a major domain of pharmaceutical discovery.
The identification of GPCR lead compounds and their optimization are now structure-based …

For clear cell renal cell carcinoma (ccRCC), lipid deposition plays important roles in the
development, metastasis, and drug resistance. However, the molecular mechanisms …

Lysophosphatidic acid (LPA) refers to a family of simple phospholipids that act as ligands for
G protein-coupled receptors. While LPA exerts effects throughout the body in normal …

Over the past decade, some studies have addressed the therapeutic effects of omega-3
polyunsaturated fatty acids (ω-3 PUFAs) and the opposite effects of omega-6 (ω-6) PUFAs …

The G-protein coupled receptors (GPCRs) activated by free fatty acids (FFAs) have emerged
as new and exciting drug targets, due to their plausible translation from pharmacology to …

The prevalence of obesity and type 2 diabetes (T2D) is increasing worldwide, and these two
metabolic disorders are closely linked. Lifestyle modification, including weight loss and …

Background Leuprolide (LEU), a synthetic nonapeptide analog of naturally occurring
gonadotropin-releasing hormone (GnRH), could exert a direct inhibitory activity on the …