Perinatal hypoxia-ischemia remains the primary cause of acute neonatal brain injury,
leading to a high mortality rate and long-term neurological deficits, such as behavioral …

The fetus can deploy a local or systemic inflammatory response when exposed to
microorganisms or, alternatively, to non-infection-related stimuli (eg, danger signals or …

Mesenchymal stem cells have shown regenerative properties in many tissues. This feature
had originally been ascribed to their multipotency and thus their ability to differentiate into …

Chorioamnionitis is a major cause of preterm birth and brain injury. Bacterial invasion of the
chorion and amnion, and/or the placenta, can lead to a fetal inflammatory response, which in …

Background Concomitant administration of allogeneic umbilical cord blood (UCB) infusion
and erythropoietin (EPO) showed therapeutic efficacy in children with cerebral palsy (CP) …

Background aims The term “cerebral palsy”(CP) encompasses many syndromes that
emerge from brain damage at early stages of ontogenesis and manifest as the inability to …

Cerebral Palsy (CP) refers to a heterogeneous group of permanent but non-progressive
movement disorders caused by injury to the developing fetal or infant brain (Bax et al …

Perinatal tissues possess numerous types of stem (stromal) cells, which are considered
effective candidates for cell therapy. These tissues possess common characteristics of both …

Preterm birth and associated brain injury are the primary cause of cerebral palsy and
developmental disabilities and are among the most serious global health issues that modern …

Background Hypoxic ischemic (HI) insults during pregnancy and birth can result in
neurodevelopmental disorders, such as cerebral palsy. We have previously shown that a …