The defense against infectious diseases, either through natural immunity or after
vaccinations, relies on the generation and maintenance of protective T cell memory. Naïve T …

T cells are integral in mediating adaptive immunity to infection, autoimmunity, and cancer.
Upon immune challenge, T cells exit from a quiescent state, followed by clonal expansion …

Cells can rapidly adjust their proteomes in dynamic environments by regulating mRNA
translation. There is mounting evidence that dysregulation of mRNA translation supports the …

T cells are integral components of the adaptive immune system, and their responses are
mediated by unique T-cell receptors (TCR) that recognize specific antigens from a variety of …

Adaptive immunity requires the expansion of high-affinity lymphocytes from a
heterogeneous pool. Whereas current models explain this through signal transduction, we …

Early expansion and long-term persistence predict efficacy of chimeric antigen receptor T
cells (CARTs),,,,,–, but mechanisms governing effector versus memory CART differentiation …

The strength of T cell receptor (TCR) stimulation and asymmetric distribution of fate
determinants are both implied to affect T cell differentiation. Here, we uncover asymmetric …

Asymmetric cell division is a fundamental process conserved throughout evolution,
employed by both prokaryotic and eukaryotic organisms. Its significance lies in its ability to …

Centrioles define centrosome structure and function. Deregulation of centriole numbers can
cause developmental defects and cancer. The p53 tumor suppressor limits the growth of …

Ribosomal biosynthesis in nucleoli is an energy-demanding process driven by all RNA
polymerases and hundreds of auxiliary proteins. We investigated how this process is …