Recent work continues to place cholinergic circuits at center stage for normal executive and
mnemonic functioning and provides compelling evidence that the loss of cholinergic …

Alzheimer's disease (AD) is an age-related devastating neurodegenerative disorder, which
severely impacts on the global economic development and healthcare system. Though AD …

The basal forebrain cholinergic complex comprising medial septum, horizontal and vertical
diagonal band of Broca, and nucleus basalis of Meynert provides the mayor cholinergic …

Acetylcholinesterase (AChE) plays an important role in the pathogenesis of
neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative …

Alzheimer's disease (AD) is characterized by a progressive phenotypic downregulation of
markers within cholinergic basal forebrain (CBF) neurons, frank CBF cell loss and reduced …

Abstract The cholinesterase inhibitors (ChE-Is) attenuate the cholinergic deficit underlying
the cognitive and neuropsychiatric dysfunctions in patients with AD. Inhibition of brain …

In Alzheimer disease (AD), which is the most common cause of dementia, the underlying
disease pathology most probably precedes the onset of cognitive symptoms by many years …

Alzheimer's disease (AD) is a complex progressive brain degenerative disorder that has
effects on multiple cerebral systems. In addition to cognitive and functional decline, diverse …

Abstract 18 F-fluoroethoxybenzovesamicol (FEOBV) is a new PET radiotracer that binds to
the vesicular acetylcholine transporter. In both animals and healthy humans, FEOBV was …

Background Pathology reports have shown that cholinergic forebrain neuronal losses in
parkinsonian dementia (PDem) are equal to or greater than those in Alzheimer disease …