The last 20–25 years have seen an explosion of interest in the role of NADPH oxidase
(NOX) in cardiovascular function and disease. In vascular smooth muscle and endothelium …

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases regulate production of
reactive oxygen species (ROS) that cause oxidative damage to cellular components but also …

Nucleic acid-based therapeutics are currently developed at large scale for prevention and
management of cardiovascular diseases (CVDs), since:(i) genetic studies have highlighted …

The sarcoplasmic reticulum (SR) plays the key role in cardiac function as the major source of
Ca2+ that activates cardiomyocyte contractile machinery. Disturbances in finely-tuned SR …

HAX1 is a relatively small, ubiquitously expressed, predominantly mitochondrial, intrinsically
disordered protein. It has been implicated in the regulation of apoptosis, cell migration …

Cardiomyocyte contraction relies on precisely regulated intracellular Ca 2+ signaling
through various Ca 2+ channels and transporters. In this article, we will review the …

Key points Advanced maternal age increases the risk of pregnancy complications such as
fetal growth restriction, hypertension and premature birth. Offspring born from compromised …

Heat shock protein 90 (Hsp90) is a molecular chaperone that interacts with up to 10% of the
proteome. The extensive involvement in protein folding and regulation of protein stability …

To date, the role of hematopoietic‑substrate‑1‑associated protein X‑1 (HAX1) in liver cancer
is rarely studied. The present study explored the role of HAX1 in liver cancer. The …

Na+-K+-ATPase from mice lacking the γ subunit exhibits decreased thermal stability.
Phospholamban (PLN) and sarcolipin (SLN) are small homologous proteins that regulate …