Late onset Alzheimer's disease genetics implicates microglial pathways in disease risk

AG Efthymiou, AM Goate - Molecular neurodegeneration, 2017 - Springer
Alzheimer's disease (AD) is a highly heritable complex disease with no current effective
prevention or treatment. The majority of drugs developed for AD focus on the amyloid …

A global view of the genetic basis of Alzheimer disease

C Reitz, MA Pericak-Vance, T Foroud… - Nature Reviews …, 2023 - nature.com
The risk of Alzheimer disease (AD) increases with age, family history and informative genetic
variants. Sadly, there is still no cure or means of prevention. As in other complex diseases …

2018 Alzheimer's disease facts and figures

Alzheimer's Association - Alzheimer's & Dementia, 2018 - Elsevier
This article describes the public health impact of Alzheimer's disease (AD), including
incidence and prevalence, mortality and morbidity, costs of care, and the overall impact on …

Integration of Alzheimer's disease genetics and myeloid genomics identifies disease risk regulatory elements and genes

G Novikova, M Kapoor, J Tcw, EM Abud… - Nature …, 2021 - nature.com
Genome-wide association studies (GWAS) have identified more than 40 loci associated with
Alzheimer's disease (AD), but the causal variants, regulatory elements, genes and pathways …

Novel Alzheimer disease risk loci and pathways in African American individuals using the African genome resources panel: a meta-analysis

BW Kunkle, M Schmidt, HU Klein, AC Naj… - JAMA …, 2021 - jamanetwork.com
Importance Compared with non-Hispanic White individuals, African American individuals
from the same community are approximately twice as likely to develop Alzheimer disease …

2016 Alzheimer's disease facts and figures

Alzheimer's Association - Alzheimer's & Dementia, 2016 - Elsevier
This report describes the public health impact of Alzheimer's disease, including incidence
and prevalence, mortality rates, costs of care, and the overall impact on caregivers and …

2017 Alzheimer's disease facts and figures

Alzheimer's Association - Alzheimer's & Dementia, 2017 - Elsevier
This article describes the public health impact of Alzheimer's disease (AD), including
incidence and prevalence, mortality rates, costs of care, and the overall impact on caregivers …

2015 Alzheimer's disease facts and figures

Alzheimer's Association - Alzheimer's & Dementia, 2015 - Wiley Online Library
This report discusses the public health impact of Alzheimer's disease (AD), including
incidence and prevalence, mortality rates, costs of care and the overall effect on caregivers …

Assessment of racial disparities in biomarkers for Alzheimer disease

JC Morris, SE Schindler, LM McCue, KL Moulder… - JAMA …, 2019 - jamanetwork.com
Importance Racial differences in molecular biomarkers for Alzheimer disease may suggest
race-dependent biological mechanisms. Objective To ascertain whether there are racial …

Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers

C Reitz, R Mayeux - Biochemical pharmacology, 2014 - Elsevier
The global prevalence of dementia is as high as 24 million, and has been predicted to
quadruple by the year 2050. In the US alone, Alzheimer disease (AD)–the most frequent …