Immune checkpoint therapy (ICT) has dramatically altered clinical outcomes for cancer
patients and conferred durable clinical benefits, including cure in a subset of patients …

Myeloid cells are pivotal within the immunosuppressive tumour microenvironment. The
accumulation of tumour-modified myeloid cells derived from monocytes or neutrophils …

Glioblastoma (GBM), a highly lethal brain cancer, is notorious for immunosuppression, but
the mechanisms remain unclear. Here, we documented a temporospatial patterning of tumor …

Neutrophils are abundant immune cells in the circulation and frequently infiltrate tumors in
substantial numbers. However, their precise functions in different cancer types remain …

Diffuse midline glioma-H3K27M mutant (DMG) and glioblastoma (GBM) are the most lethal
brain tumors that primarily occur in pediatric and adult patients, respectively. Both tumors …

Malignant gliomas are largely refractory to immune checkpoint blockade (ICB) therapy. To
explore the underlying immune regulators, we examine the microenvironment in glioma and …

Brain macrophages include microglia in the parenchyma, border-associated macrophages
in the meningeal-choroid plexus-perivascular space, and monocyte-derived macrophages …

High-grade gliomas, the most common and aggressive primary brain tumors, are
characterized by a complex tumor microenvironment (TME). Among the immune cells …

Abstract ABSTRACT: Colony-Stimulating Factor-1 Receptor (CSF1R) is a receptor tyrosine
kinase that controls the differentiation and maintenance of most tissue-resident …

Simple Summary Macrophages are a specialized immune cell type found in both
invertebrates and vertebrates. Versatile in functionality, macrophages carry out important …