For decades, insight into fundamental principles of human biology and disease has been
obtained primarily by experiments in animal models. While this has allowed researchers to …

The field of single-cell genomics and spatial technologies is rapidly evolving and has
already provided unprecedented insights into complex tissues. Major advances have been …

Mapping gene networks requires large amounts of transcriptomic data to learn the
connections between genes, which impedes discoveries in settings with limited data …

Human pluripotent stem-cell-derived organoids are models for human development and
disease. We report a modified human kidney organoid system that generates thousands of …

During development, distinct progenitors contribute to the nephrons versus the ureteric
epithelium of the kidney. Indeed, previous human pluripotent stem-cell-derived models of …

While pluripotent stem cell-derived kidney organoids are now being used to model renal
disease, the proximal nephron remains immature with limited evidence for key functional …

The use of biomimetic models of the glomerulus has the potential to improve our
understanding of the pathogenesis of kidney diseases and to enable progress in …

Kidney organoids have enabled modeling of human development and disease. While
methods of generating the nephron lineage are well established, new protocols to induce …

The extracellular matrix (ECM) is a complex network of biomolecules that mechanically and
biochemically directs cell behavior and is crucial for maintaining tissue function and health …

In the past five years, pluripotent stem cell (PSC)-derived kidney organoids and adult stem
or progenitor cell (ASC)-based kidney tubuloids have emerged as advanced in vitro models …