Cancer immunotherapy has been firmly established as a new milestone for cancer therapy,
with the development of multiple immune cells as therapeutic tools. Natural killer (NK) cells …

Highlights•NKG2D pathway is significant for both innate and adoptive tumor
immunity.•Soluble and membrane-bound NKG2D ligands confer opposite role in tumor …

Background Immunotherapies still fail to benefit colorectal cancer (CRC) patients. Relevant
functional assays aimed at studying these failures and the efficacy of cancer immunotherapy …

NK cells are a major component of the antitumor immune response and are involved in
controlling tumor progression and metastases in animal models. Here, we show that …

The induction of cellular senescence is an important mechanism by which p53 suppresses
tumorigenesis. Using a mouse model of liver carcinoma, where cellular senescence is …

It is well established that natural killer (NK) cells are involved in both innate and adaptive
immunity. Indeed, they can recognize molecules induced at the cell surface by stress signals …

Immune checkpoint inhibitors (ICI) revolutionized the field of immuno-oncology and opened
new avenues towards the development of novel assets to achieve durable immune control …

Abstract The Natural Killer Group 2D (NKG2D) receptor plays an important role in protecting
the host from infections and cancer. By recognizing ligands induced on infected or tumor …

The field of immunotherapy for solid tumors, such as prostate cancer, has been recently
focusing on therapies that can counter tumor-mediated immunosuppression. Precise …

Natural killer cells are powerful effectors of innate immunity that constitute a first line of
defense against cancer. NK cells express an array of germline-encoded receptors which …