Cancer is a major health concern worldwide and is still in a continuous surge of seeking for
effective treatments. Since the discovery of RNAi and their mechanism of action, it has …

RNA interference (RNAi) is a major cellular mechanism regulating gene expression in which
short double-stranded RNA molecules called small interfering RNA (siRNA) mediate …

Nanoparticle (NP)-based mRNA cancer vaccines hold great promise to realize personalized
cancer treatments. To advance this technology requires delivery formulations for efficient …

Radiotherapy-resistant glioblastoma (rrGBM) remains a significant clinical challenge
because of high infiltrative growth characterized by activation of antiapoptotic signal …

Glioblastoma (GBM) is an aggressive central nervous system cancer with a dismal
prognosis. The standard of care involves surgical resection followed by radiotherapy and …

Noninvasive sonodynamic therapy (SDT) shows promise for brain glioma treatment due to
deep tissue‐penetrating capabilities (> 10 cm) of ultrasound and high spatial resolutions …

With the booming development of nanomedicine, mild photothermal therapy (mPTT, 42–45°
C) has exhibited promising potential in tumor therapy. Compared with traditional PTT (> 50° …

Genetic medicine has great potential to treat the underlying causes of many human
diseases with exquisite precision, but the field has historically been stymied by delivery as …

Nonviral nanoparticles have emerged as an attractive alternative to viral vectors for gene
therapy applications, utilizing a range of lipid‐based, polymeric, and inorganic materials …

Targeted delivery of nucleic acid therapeutics to the lungs could transform treatment options
for pulmonary disease. We have previously developed oligomeric charge-altering …