A look beyond the priority: A systematic review of the genotoxic, mutagenic, and carcinogenic endpoints of non-priority PAHs
FC da Silva Junior, MBMC Felipe, DEF de Castro… - Environmental …, 2021 - Elsevier
Abstract Knowledge of the toxic potential of polycyclic aromatic hydrocarbons (PAHs) has
increased over time. Much of this knowledge is about the 16 United States-Environmental …
increased over time. Much of this knowledge is about the 16 United States-Environmental …
Aflatoxin B1-induced DNA damage and its repair
LL Bedard, TE Massey - Cancer letters, 2006 - Elsevier
Aflatoxin B1 (AFB1)-N7-guanine is the predominant adduct formed upon the reaction of
AFB1-8, 9-exo-epoxide with guanine residues in DNA. AFB1-N7-guanine can convert to the …
AFB1-8, 9-exo-epoxide with guanine residues in DNA. AFB1-N7-guanine can convert to the …
Interactions between polycyclic aromatic hydrocarbons in complex mixtures and implications for cancer risk assessment
In this review we discuss the effects of exposure to complex PAH mixtures in vitro and in vivo
on mechanisms related to carcinogenesis. Of particular concern regarding exposure to …
on mechanisms related to carcinogenesis. Of particular concern regarding exposure to …
Polycyclic aromatic hydrocarbons as skin carcinogens: comparison of benzo [a] pyrene, dibenzo [def, p] chrysene and three environmental mixtures in the FVB/N …
LK Siddens, A Larkin, SK Krueger, CA Bradfield… - Toxicology and applied …, 2012 - Elsevier
The polycyclic aromatic hydrocarbon (PAH), benzo [a] pyrene (BaP), was compared to
dibenzo [def, p] chrysene (DBC) and combinations of three environmental PAH mixtures …
dibenzo [def, p] chrysene (DBC) and combinations of three environmental PAH mixtures …
Exposure to polycyclic aromatic hydrocarbons: bulky DNA adducts and cellular responses
F Henkler, K Stolpmann, A Luch - Molecular, Clinical and Environmental …, 2012 - Springer
Environmental and dietary carcinogens such as polycyclic aromatic hydrocarbons (PAHs)
have been intensively studied for decades. Although the genotoxicity of these compounds is …
have been intensively studied for decades. Although the genotoxicity of these compounds is …
Repair-resistant DNA lesions
NE Geacintov, S Broyde - Chemical research in toxicology, 2017 - ACS Publications
The eukaryotic global genomic nucleotide excision repair (GG-NER) pathway is the major
mechanism that removes most bulky and some nonbulky lesions from cellular DNA. There is …
mechanism that removes most bulky and some nonbulky lesions from cellular DNA. There is …
Benzo [a] pyrene represses DNA repair through altered E2F1/E2F4 function marking an early event in DNA damage-induced cellular senescence
S Allmann, L Mayer, J Olma, B Kaina… - Nucleic acids …, 2020 - academic.oup.com
Transcriptional regulation of DNA repair is of outmost importance for the restoration of DNA
integrity upon genotoxic stress. Here we report that the potent environmental carcinogen …
integrity upon genotoxic stress. Here we report that the potent environmental carcinogen …
[图书][B] The chemical biology of DNA damage
NE Geacintov, S Broyde - 2010 - Wiley Online Library
XVI Preface features of DNA lesions that after the normal structural features of the DNA
molecule. If these lesions are not removed by cellular DNA repair mechanisms, DNA …
molecule. If these lesions are not removed by cellular DNA repair mechanisms, DNA …
Carcinogenesis of the oral cavity: environmental causes and potential prevention by black raspberry
K El-Bayoumy, KM Chen, SM Zhang… - Chemical research in …, 2017 - ACS Publications
Worldwide, cancers of the oral cavity and pharynx comprise the sixth most common
malignancies. Histologically, more than 90% of oral cancers are squamous cell carcinoma …
malignancies. Histologically, more than 90% of oral cancers are squamous cell carcinoma …
Adaptive upregulation of DNA repair genes following benzo (a) pyrene diol epoxide protects against cell death at the expense of mutations
M Christmann, C Boisseau, R Kitzinger… - Nucleic acids …, 2016 - academic.oup.com
A coordinated and faithful DNA damage response is of central importance for maintaining
genomic integrity and survival. Here, we show that exposure of human cells to benzo (a) …
genomic integrity and survival. Here, we show that exposure of human cells to benzo (a) …