Klotho is an identified longevity gene with beneficial pleiotropic effects on the kidney.
Evidence shows that a decline in serum Klotho level occurs in early chronic kidney disease …

Osteoporosis and Alzheimer's disease (AD) are both degenerative diseases. Osteoporosis
often proceeds cognitive deficits, and multiple studies have revealed common triggers that …

The aging-protective gene α-Klotho (KL) produces two main transcripts. The full-length
mRNA generates a transmembrane protein that after proteolytic ectodomain shedding can …

Background Periodontitis is an inflammatory disease characterized by inflammation and
progressive destruction of periodontal tissues including alveolar bone. α-klotho protein is a …

Mammalian olfactory epithelium has the capacity of self-renewal throughout life. Aging is
one of the major causes leading to the olfactory dysfunction. Here, we performed single-cell …

The change of serum soluble Klotho (sKlotho) content is related to a variety of
osteoarthropathy. However, its association with the severity of skeletal fluorosis (SF) is not …

Klotho is an antiaging protein that has multiple functions. The purpose of this study is to
investigate whether soluble klotho plays a role in cellular stress response pathways. We …

Periodontitis is one of the most common chronic inflammations of the oral cavity, which
eventually leads to tooth loss. Betulinic acid (BetA) is an organic acid that has anti …

Zebrafish are increasingly becoming an important model organism for studying the
pathophysiological mechanisms of human diseases and investigating how these …

Simple Summary Osteoporosis is a significant public health issue around the world, with
post-menopausal osteoporosis due to estrogen deficiency resulting in approximately ¾ of …