From mice to women: the conundrum of immunity to infection during pregnancy

L Krishnan, T Nguyen, S McComb - Journal of reproductive immunology, 2013 - Elsevier
Resistance to infection is the ability of the host to evoke a strong immune response sufficient
to eliminate the infectious agent. In contrast, maternal tolerance to the fetus necessitates …

Immunogenetics of Toxoplasma gondii informs vaccine design

FL Henriquez, S Woods, H Cong, R McLeod… - Trends in …, 2010 - cell.com
A series of studies over 20 years mapped resistance to toxoplasmic encephalitis in mice to
major histocompatibility complex class I (MHC I) and ultimately, more precisely the Ld …

Exosomes are an effective vaccine against congenital toxoplasmosis in mice

C Beauvillain, MO Juste, S Dion, J Pierre… - Vaccine, 2009 - Elsevier
Toxoplasmosis is a serious disease in humans and may cause abortion or congenital
infection if a woman is exposed to the disease for the first time during pregnancy. Infection …

Live Attenuated Pru:Δcdpk2 Strain of Toxoplasma gondii Protects Against Acute, Chronic, and Congenital Toxoplasmosis

JL Wang, TT Li, HM Elsheikha, K Chen… - The Journal of …, 2018 - academic.oup.com
Abstract Background The threat of Toxoplasma gondii infection in immunocompromised
individuals and pregnant women necessitates the development of a safe and effective …

Toxoplasma gondii tkl1 deletion mutant is a promising vaccine against acute, chronic, and congenital toxoplasmosis in mice

JL Wang, QL Liang, TT Li, JJ He, MJ Bai… - The Journal of …, 2020 - journals.aai.org
In this study, we generated a tkl1 deletion mutant in the Toxoplasma gondii type 1 RH
(RHΔtkl1) strain and tested the protective efficacies of vaccination using RHΔtkl1 tachyzoites …

Vaccines in congenital toxoplasmosis: advances and perspectives

M Barros, D Teixeira, M Vilanova, A Correia… - Frontiers in …, 2021 - frontiersin.org
Congenital toxoplasmosis has a high impact on human disease worldwide, inducing serious
consequences from fetus to adulthood. Despite this, there are currently no human vaccines …

Neuropsychiatric manifestations of latent toxoplasmosis on mothers and their offspring

A Abdoli, A Dalimi, M Arbabi… - The Journal of Maternal …, 2014 - Taylor & Francis
Toxoplasmosis is one of the most common parasitic diseases worldwide. It is estimated that
approximately one-third of the world's population is latently infected. Infection generally …

Toxoplasma gondii infection in goats: serological, pathological, and clinical monitoring during gestation

JMB de Oliveira, BP Silva, M Ribeiro-Andrade… - Parasitology …, 2022 - Springer
This study aimed to evaluate Toxoplasma gondii infection in pregnant goats. The goats were
divided into two groups: group one (G1) comprised of 31 pregnant goats naturally infected …

The promise of placental extracellular vesicles: models and challenges for diagnosing placental dysfunction in utero

LN Block, BD Bowman, JK Schmidt… - Biology of …, 2021 - academic.oup.com
Monitoring the health of a pregnancy is of utmost importance to both the fetus and the
mother. The diagnosis of pregnancy complications typically occurs after the manifestation of …

New adjuvanted vaccines in pregnancy: what is known about their safety?

C Herberts, B Melgert, JW Laan… - Expert review of vaccines, 2010 - Taylor & Francis
The recent introduction of oil-in-water emulsions as adjuvants in several pandemic vaccines,
such as the H1N1 vaccine, has challenged regulatory authorities to establish their safety in …