Matrix metalloproteinases (MMPs) are the major protease family responsible for the
cleavage of the matrisome (global composition of the extracellular matrix (ECM) proteome) …

Bone tissue has the capacity to adapt to its functional environment such that its morphology
is “optimized” for the mechanical demand. The adaptive nature of the skeleton poses an …

Bone has the ability to adjust its structure to meet its mechanical environment. The prevailing
view of bone mechanobiology is that osteocytes are responsible for detecting and …

The potential for brief periods of lowmagnitude, highfrequency mechanical signals to
enhance the musculoskeletal system was evaluated in young women with low BMD. Twelve …

Mesenchymal stem cells (MSCs) are defined by their ability to selfrenew and differentiate
into the cells that form mesodermal tissues such as bone and fat. Low magnitude …

Bone and muscle tissues influence each other through the integration of mechanical and
biochemical signals, giving rise to bone–muscle crosstalk. They are also known to secrete …

Obesity, a global pandemic that debilitates millions of people and burdens society with tens
of billions of dollars in health care costs, is deterred by exercise. Although it is presumed that …

A cell's ability to recognize and adapt to the physical environment is central to its survival
and function, but how mechanical cues are perceived and transduced into intracellular …

Our systematic review and meta-analysis of randomized controlled trials (RCTs) examining
whole-body vibration (WBV) effect on bone mineral density (BMD) found significant but small …

Extracellular matrix production and degradation by bone cells are critical steps in bone
metabolism. Mutations of the gene encoding MMP-2, an extracellular matrix-degrading …