Yin Yang 1 (YY1), a dual function transcription factor, is known to regulate transcriptional
activation and repression of many genes associated with multiple cellular processes …

Tumorigenesis is a multistep process characterized by the acquisition of genetic and
epigenetic alterations. During the course of malignancy development, tumor cells acquire …

Simple Summary Cancer is a global health problem with severe consequences. Certain
genes, known as transcription factors (TFs), are overactive in many tumors. Targeting these …

In recent years, thyroid malignances have become more prevalent, especially among
women. The most common sporadic types of thyroid tumors of follicular origin include …

We aimed to evaluate the diagnostic utility of the novel immunohistochemical marker TROP-
2 on thyroid specimens (226 tumours and 207 controls). Whole slide immunohistochemistry …

ABSTRACT MicroR‐141‐3p has been found to be downregulated in papillary thyroid
carcinoma (PTC), while little is known about the cellular functions and precise signals …

Molecular mechanisms underlying the pathogenesis and progression of malignant thyroid
cancers, such as follicular thyroid carcinomas (FTCs), and how these differ from benign …

Sentrin specific-protease 1 (SENP1) is a protein involved in deSUMOylation that is almost
overexpressed in cancer. SENP1 has a determinative role in the activation of transcription …

Background Hashimoto's thyroiditis (HT) is a chronic autoimmune disease that poses a risk
factor for papillary thyroid carcinoma (PTC). The present study aimed to identify the key …

Abstract MicroRNA-497 (miR-497) has been reported to be a tumor-suppressive miRNA in
thyroid cancer (TC), yet the mechanism is not clearly defined. In this study, we aim to …