mRNA vaccines in the prevention and treatment of diseases

Y Gu, J Duan, N Yang, Y Yang, X Zhao - MedComm, 2022 - Wiley Online Library
Messenger ribonucleic acid (mRNA) vaccines made their successful public debut in the
effort against the COVID‐19 outbreak starting in late 2019, although the history of mRNA …

The Battle for Survival: The Role of RNA Non-Canonical Tails in the Virus–Host Interaction

X Wen, A Irshad, H Jin - Metabolites, 2023 - mdpi.com
Terminal nucleotidyltransferases (TENTs) could generate a 'mixed tail'or 'U-rich
tail'consisting of different nucleotides at the 3′ end of RNA by non-templated nucleotide …

Uncovering a mammalian neural-specific poly (A) binding protein with unique properties

S Sharma, S Kajjo, Z Harra, B Hasaj… - Genes & …, 2023 - genesdev.cshlp.org
Abstract The mRNA 3′ poly (A) tail plays a critical role in regulating both mRNA translation
and turnover. It is bound by the cytoplasmic poly (A) binding protein (PABPC), an …

Lyotropic Liquid Crystalline Phase Nanostructure and Cholesterol Enhance Lipid Nanoparticle Mediated mRNA Transfection in Macrophages

J Iscaro, H Yu, N Martinez… - Advanced Functional …, 2024 - Wiley Online Library
Macrophages are unique immune cells attracting growing attention as a potential candidate
for cell‐based therapy for infectious diseases and cancer. Strategies that can reprogramme …

Pleiotropic effects of PAB1 deletion: Extensive changes in the yeast proteome, transcriptome, and translatome

K Mangkalaphiban, R Ganesan, A Jacobson - PLoS genetics, 2024 - journals.plos.org
Cytoplasmic poly (A)-binding protein (PABPC; Pab1 in yeast) is thought to be involved in
multiple steps of post-transcriptional control, including translation initiation, translation …

Comparative genomics and interactomics of polyadenylation factors for the prediction of new parasite targets: Entamoeba histolytica as a working model

RG Avila-Bonilla, JA Velazquez-Guzman… - Bioscience …, 2023 - portlandpress.com
Protein–protein interactions (PPI) play a key role in predicting the function of a target protein
and drug ability to affect an entire biological system. Prediction of PPI networks greatly …

Yeast poly (A)-binding protein (Pab1) controls translation initiation in vivo primarily by blocking mRNA decapping and decay

P Poonia, V Valabhoju, T Li, J Iben, X Niu, Z Lin… - bioRxiv, 2024 - biorxiv.org
Poly (A)-binding protein (Pab1 in yeast) is involved in mRNA decay and translation initiation,
but its molecular functions are incompletely understood. We found that auxin-induced …

[HTML][HTML] Direct and indirect consequences of PAB1 deletion in the regulation of translation initiation, translation termination, and mRNA decay

K Mangkalaphiban, R Ganesan, A Jacobson - bioRxiv, 2023 - ncbi.nlm.nih.gov
Cytoplasmic poly (A)-binding protein (PABPC; Pab1 in yeast) is thought to be involved in
multiple steps of post-transcriptional control, including translation initiation, translation …

Tethered mRNA Amplifier: A Novel Approach to Increase Protein Expression

B Torkzaban, A Sponaugle, J Coller - Deadenylation: Methods and …, 2023 - Springer
Posttranscriptional RNA modification has become a revolutionary clinical tool to improve the
underlying condition in genetic disorders. The cell achieves translational regulation through …

Characterization of a mammalian neural-specific poly (A) binding protein with unique properties

S Sharma - 2024 - escholarship.mcgill.ca
Earliest microfossils provide evidence that first single cell eukaryotes appeared around 1.5
billion years ago (1). During the course of evolution, eukaryotic single cell organisms formed …