Metabolic related diseases, such as type 2 diabetes, metabolic syndrome, and nonalcoholic
fatty liver disease (NAFLD), are widespread threats which bring about a significant burden of …

Background Peroxisome proliferator‐activated receptors (PPARs) are ligand‐activated
transcription factors known to regulate glucose and fatty acid metabolism, inflammation …

The pro-longevity enzyme SIRT6 regulates various metabolic pathways. Gene expression
analyses in SIRT6 heterozygotic mice identify significant decreases in PPARα signaling …

Background & Aims PARP1 is a key mediator of cellular stress responses and critical in
multiple physiological and pathophysiological processes of cells. However, whether it is …

The liver plays a central role in the regulation of fatty acid metabolism. Hepatocytes are
highly sensitive to nutrients and hormones that drive extensive transcriptional responses …

Objective Storage of triglycerides in lipid droplets is governed by a set of lipid droplet-
associated proteins. One of these lipid droplet-associated proteins, hypoxia-inducible lipid …

Background Studies in mice have shown that PPARα is an important regulator of lipid
metabolism in liver and key transcription factor involved in the adaptive response to fasting …

Background The role of PPARα in gene regulation in mouse liver is well characterized.
However, less is known about the role of PPARα in human liver. The aim of the present …

Aim: Tafazzin knockdown (TazKD) in mice is widely used to create an experimental model of
Barth syndrome (BTHS) that exhibits dilated cardiomyopathy and impaired exercise …

As the main metabolic and detoxification organ, the liver constantly adapts its activity to fulfill
the energy requirements of the whole body. Despite the remarkable adaptive capacity of the …