Molecular mechanisms and physiological functions of mitophagy
Degradation of mitochondria via a selective form of autophagy, named mitophagy, is a
fundamental mechanism conserved from yeast to humans that regulates mitochondrial …
fundamental mechanism conserved from yeast to humans that regulates mitochondrial …
Mitochondrial quality control in health and in Parkinson's disease
As a central hub for cellular metabolism and intracellular signaling, the mitochondrion is a
pivotal organelle, dysfunction of which has been linked to several human diseases including …
pivotal organelle, dysfunction of which has been linked to several human diseases including …
Regulation of mitochondrial biogenesis as a way for active longevity: interaction between the Nrf2 and PGC-1α signaling pathways
Aging is a general degenerative process related to deterioration of cell functions in the entire
organism. Mitochondria, which play a key role in energy homeostasis and metabolism of …
organism. Mitochondria, which play a key role in energy homeostasis and metabolism of …
Calcium signaling regulates autophagy and apoptosis
Calcium (Ca2+) functions as a second messenger that is critical in regulating fundamental
physiological functions such as cell growth/development, cell survival, neuronal …
physiological functions such as cell growth/development, cell survival, neuronal …
Macroautophagy in CNS health and disease
CJ Griffey, A Yamamoto - Nature Reviews Neuroscience, 2022 - nature.com
Macroautophagy is an evolutionarily conserved process that delivers diverse cellular
contents to lysosomes for degradation. As our understanding of this pathway grows, so does …
contents to lysosomes for degradation. As our understanding of this pathway grows, so does …
Autophagy in Parkinson's disease
Impaired protein homeostasis and accumulation of damaged or abnormally modified protein
are common disease mechanisms in many neurodegenerative disorders, including …
are common disease mechanisms in many neurodegenerative disorders, including …
Building and decoding ubiquitin chains for mitophagy
Mitochondria produce energy in the form of ATP via oxidative phosphorylation. As defects in
oxidative phosphorylation can generate harmful reactive oxygen species, it is important that …
oxidative phosphorylation can generate harmful reactive oxygen species, it is important that …
Necrotic, apoptotic and autophagic cell fates triggered by nanoparticles
R Mohammadinejad, MA Moosavi, S Tavakol… - Autophagy, 2019 - Taylor & Francis
Nanomaterials have gained a rapid increase in use in a variety of applications that pertain to
many aspects of human life. The majority of these innovations are centered on medical …
many aspects of human life. The majority of these innovations are centered on medical …
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease
AM Pickrell, RJ Youle - Neuron, 2015 - cell.com
Understanding the function of genes mutated in hereditary forms of Parkinson's disease
yields insight into disease etiology and reveals new pathways in cell biology. Although …
yields insight into disease etiology and reveals new pathways in cell biology. Although …
The PINK1-PARKIN mitochondrial ubiquitylation pathway drives a program of OPTN/NDP52 recruitment and TBK1 activation to promote mitophagy
Damaged mitochondria are detrimental to cellular homeostasis. One mechanism for removal
of damaged mitochondria involves the PINK1-PARKIN pathway, which poly-ubiquitylates …
of damaged mitochondria involves the PINK1-PARKIN pathway, which poly-ubiquitylates …