Mechanical circulatory support (MCS) evolved from an engineering dream to clinical reality
during the 1980s when increasing numbers of patients were dying on heart transplant wait …

Left ventricular assist-device (LVAD) implantation is a life-saving therapy for patients with
advanced heart failure (HF). With chronic unloading and circulatory support, LVAD …

Long-term mechanical circulatory support (LT-MCS) is an important treatment modality for
patients with severe heart failure. Different devices are available, and many—sometimes …

Background: The number of centers with left ventricular assist device (LVAD) research
programs focused on cardiac recovery is very small. Therefore, this phenomenon has been …

Myocardial remodeling induced by pressure and volume overload drives the vicious cycle of
progressive myocardial dysfunction in chronic heart failure (HF). Mechanical volume and …

Background Acutely decompensated heart failure presents a complicated challenge.
Established temporary support measures have significant adverse effects. A minimally …

Recovery of cardiac function is the holy grail of heart failure therapy yet is infrequently
observed and remains poorly understood. In this study, we performed single-nucleus RNA …

OBJECTIVES A small percentage of paediatric patients supported with a ventricular assist
device (VAD) can have their device explanted following myocardial recovery. The goal of …

The medical burden of heart failure (HF) has spurred interest in clinicians and scientists to
develop therapies to restore the function of a failing heart. To advance this agenda, the …

Despite> 100 clinical trials, only 2 new drugs had been approved by the US Food and Drug
Administration for the treatment of chronic heart failure in more than a decade: the …