Background Randomized trials investigating the efficacy of aminosalicylates for the
treatment of mildly to moderately active Crohn's disease have yielded conflicting results. A …

A subset of patients with ulcerative colitis (UC) present with, or progress to, moderate to
severe disease activity. These patients are at high risk for colectomy, hospitalization …

Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory diseases of the
gastrointestinal tract. While a cure remains elusive, both can be treated with medications that …

Background Debate exists regarding to whether thiopurine therapy is as effective in
ulcerative colitis (UC) as it is in Crohn's disease. Aim To review systematically the efficacy of …

Background Thiopurines have proven efficacy in long-term maintenance therapy of
inflammatory bowel disease (IBD). Limited data are available with regard to factors …

Ulcerative colitis (UC) is a chronic disease of the GI tract that is characterized by mucosal
inflammation in the colon. Mesalamine (mesalazine) is a 5-aminosalicylic acid compound …

ABSTRACT Introduction: For 30 years, 5-aminosalicylic acid (5-ASA) has been the
backbone of therapeutic management in patients with ulcerative colitis (UC). In the biologic …

There continue to be evolutionary changes in the management of ulcerative colitis despite
the fact that, aside from a variety of aminosalicylate formulations, no new therapies have …

Sulfasalazine and mesalazine (also known as mesalamine; 5-aminosalicylic acid)
preparations have for many years been used for the treatment of IBD (ie ulcerative colitis …

AIM To prospectively evaluate whether a relationship between thiopurine methyltransferase
(TPMT) activity and incidence of adverse effects (especially myelotoxicity) exists, in a long …