The Major Histocompatibility Complex (MHC) locus encodes classical MHC class I and MHC
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …

T cells are a critical part of the adaptive immune system that are able to distinguish between
healthy and unhealthy cells. Upon recognition of protein fragments (peptides), activated T …

Deep learning algorithms have been utilized to achieve enhanced performance in pattern-
recognition tasks. The ability to learn complex patterns in data has tremendous implications …

T cells are defined by a heterodimeric surface receptor, the T cell receptor (TCR), that
mediates recognition of pathogen-associated epitopes through interactions with peptide and …

The ability to decode antigen specificities encapsulated in the sequences of rearranged T-
cell receptor (TCR) genes is critical for our understanding of the adaptive immune system …

Motivation While growing numbers of T cell receptor (TCR) repertoires are being mapped by
high-throughput sequencing, existing methods do not allow for computationally connecting a …

Clonal selection theory proposed that individual T cells are specific for a single peptide–
MHC antigen. However, the repertoire of αβ T cell receptors (TCRs) is dwarfed by the vast …

T cell receptor (TCR) antigen–specific recognition is essential for the adaptive immune
system. However, building a TCR-antigen interaction map has been challenging due to the …

Dendritic cells (DCs) are the key professional antigen-presenting cells which bridge innate
and adaptive immune responses, inducing the priming and differentiation of naive to effector …

The diversity of antigen receptors and the specificity it underlies are the hallmarks of the
cellular arm of the adaptive immune system. T and B lymphocytes are indeed truly unique in …