[HTML][HTML] The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis
L Zheng, Z Zhang, P Sheng, A Mobasheri - Ageing research reviews, 2021 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease characterized by low-grade inflammation
and high levels of clinical heterogeneity. Aberrant chondrocyte metabolism is a response to …
and high levels of clinical heterogeneity. Aberrant chondrocyte metabolism is a response to …
NF-κB signaling pathways in osteoarthritic cartilage destruction
MC Choi, J Jo, J Park, HK Kang, Y Park - Cells, 2019 - mdpi.com
Osteoarthritis (OA) is a type of joint disease associated with wear and tear, inflammation,
and aging. Mechanical stress along with synovial inflammation promotes the degradation of …
and aging. Mechanical stress along with synovial inflammation promotes the degradation of …
Insights on molecular mechanisms of chondrocytes death in osteoarthritis
E Charlier, B Relic, C Deroyer, O Malaise… - International journal of …, 2016 - mdpi.com
Osteoarthritis (OA) is a joint pathology characterized by progressive cartilage degradation.
Medical care is mainly based on alleviating pain symptoms. Compelling studies report the …
Medical care is mainly based on alleviating pain symptoms. Compelling studies report the …
Molecular mechanisms of N-acetylcysteine actions
M Zafarullah, WQ Li, J Sylvester, M Ahmad - Cellular and Molecular Life …, 2003 - Springer
Oxidative stress generated by an imbalance between reactive oxygen species (ROS) and
antioxidants contributes to the pathogenesis of arthritis, cancer, cardiovascular, liver and …
antioxidants contributes to the pathogenesis of arthritis, cancer, cardiovascular, liver and …
Articular cartilage and changes in arthritis: cell biology of osteoarthritis
LJ Sandell, T Aigner - Arthritis research & therapy, 2001 - Springer
The reaction patterns of chondrocytes in osteoarthritis can be summarized in five
categories:(1) proliferation and cell death (apoptosis); changes in (2) synthetic activity and …
categories:(1) proliferation and cell death (apoptosis); changes in (2) synthetic activity and …
The role of mitochondria in osteoarthritis
FJ Blanco, I Rego, C Ruiz-Romero - Nature Reviews Rheumatology, 2011 - nature.com
Mitochondria are important regulators of cellular function and survival that may have a key
role in aging-related diseases. Mitochondrial DNA (mtDNA) mutations and oxidative …
role in aging-related diseases. Mitochondrial DNA (mtDNA) mutations and oxidative …
Effects of aging on articular cartilage homeostasis
M Lotz, RF Loeser - Bone, 2012 - Elsevier
This review is focused on aging-related changes in cells and extracellular matrix of the
articular cartilage. Major extracellular matrix changes are a reduced thickness of cartilage …
articular cartilage. Major extracellular matrix changes are a reduced thickness of cartilage …
Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action
LW Moreland - Arthritis Res Ther, 2003 - Springer
Although the predominant mechanism of intra-articular hyaluronan (hyaluronic acid)(HA)
and hylans for the treatment of pain associated with knee osteoarthritis (OA) is unknown, in …
and hylans for the treatment of pain associated with knee osteoarthritis (OA) is unknown, in …
Matrix vesicles and calcification
HC Anderson - Current rheumatology reports, 2003 - Springer
Matrix vesicles (MVs) are extracellular, 100 nM in diameter, membrane-invested particles
selectively located at sites of initial calcification in cartilage, bone, and predentin. The first …
selectively located at sites of initial calcification in cartilage, bone, and predentin. The first …
Etiology of osteoarthritis: genetics and synovial joint development
LJ Sandell - Nature Reviews Rheumatology, 2012 - nature.com
Osteoarthritis (OA) has a considerable hereditary component and is considered to be a
polygenic disease. Data derived from genetic analyses and genome-wide screening of …
polygenic disease. Data derived from genetic analyses and genome-wide screening of …